Results 31 to 40 of about 350,877 (266)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Heat Treatment and Fracture Behavior of Aluminum/Steel FSW Joints: A Comprehensive Analysis of a Curved Interface

Journal of Manufacturing and Materials Processing
Joining dissimilar metals, such as aluminum and steel, presents an attractive option for creating lightweight yet durable structures. However, challenges arise from the formation of brittle intermetallic compounds (IMCs) at the interface of dissimilar ...
Tiago Oliveira Gonçalves Teixeira, Reza Beygi, Masih Bolhasani Hesari, Ricardo João Camilo Carbas, Eduardo Andre Sousa Marques, Mohammad Mehdi Kasaei, Lucas Filipe Martins da Silva   +6 more
doaj   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Ultrasonic Nanostructuring of Surface Layers of High-Chrome Steels and their Tribotechnical Properties in the Lubricant Media Modified with Ultradispersed Carbon-Containing Additive

Механика машин, механизмов и материалов, 2017
The influence of ultrasonic treatment of surface layers of steels 40X13 and 12X18H9 on their structure, durometric and tribotechnical properties was studied. It is shown that the ultrasonic treatment of these steels leads to theformation in their surface
Petr A. Vityaz, Victor Ye. Panin, Vladimir A. Kukareko, Aleksandr N. Grigorchik, Aleksandr G. Kononov, Yuriy I. Pochivalov   +5 more
doaj  

ULTIMATE STRENGTH, DUCTILITY, AND FAILURE MODE OF HIGH-STRENGTH FRICTIONAL BOLTED JOINTS MADE OF HIGH-STRENGTH STEEL [PDF]

, 2023
Zice Qin, Hideki Moriyama, Takashi Yamaguchi, Mitsuhiro Shigeishi, Yu-Yue Xing, Akira Hashimoto, P Moe, D Beg, J Lopatic, P Moe, D Beg, Y Wang, Y Lyu, G Li, J Liew, K Homma, M Tanaka, K Matsuoka, T Kasuya, H Kawasaki, C Miki, A Ichikawa, T Kusunoki, F Kawabata, D Duc, Y Okui, K Hagiwara, M Nagai, M Rahman, Y Okui, T Shoji, M Komuro, P Moe, D Beg, P Moe, Y Toda, T Yamaguchi, Y Mineyama, Naoe   +38 more
openalex   +1 more source

Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki, Satoru Noguchi, Hotake Takizawa, Yasushi Oya, Yuji Takahashi, Hirofumi Komaki, Hajime Arahata, Shinichiro Hayashi, Ichizo Nishino   +8 more
wiley   +1 more source

Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel, Charlotte Hennessey, Hannah Lee, Pia Parekh, Sheng‐Han Kuo, Ami Kumar   +5 more
wiley   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source