Results 91 to 100 of about 16,917 (307)

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

open access: yesAdvanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang   +11 more
wiley   +1 more source

Criteria for rapid sliding I.: a review of Vaiont case [PDF]

open access: yes, 2010
Vaiont slide has been represented by a model of two interacting evolutive wedges. Mass conservation during the motion implies that the upper wedge transfers mass to the lower one through an internal shearing plane.
Alonso Pérez de Agreda, Eduardo   +1 more
core   +2 more sources

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

open access: yesAdvanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu   +15 more
wiley   +1 more source

Shearing tests with continuously increasing normal stress [PDF]

open access: yes, 2006
In the conventional shearing tests the normal force or the normal stiffness are kept constant during the experiment. Sliding under constant normal load occurs in slopes if the environment is not changing during the process.
Ván, Péter, Vásárhelyi, Balázs
core   +1 more source

Analysis of operation parameters of partial backfilling in the context of selective coal mining [PDF]

open access: yes, 2019
Purpose is to determine factors of effect of mechanical parameters and geometry of packs, constructed using the undercut rocks in the process of selective coal mining, on the state of geomechanical system within a mine working-stope junction during a ...
Dereviahina, N, Malanchuk, L, Sotskov, V
core   +1 more source

Bioinspired Adaptive Leg‐Claw Enables Robust Perching and Grasping for UAVs

open access: yesAdvanced Science, EarlyView.
Inspired by owl limb morphology and bat roosting behavior, this study presents a bioinspired adaptive leg‐claw mechanism that enables UAVs to perform robust and versatile perching and grasping. The design integrates a four‐link tibial structure, tension‐driven deformable feet, and active control, enabling stable perching on various branches and ...
Tianyu Cheng   +6 more
wiley   +1 more source

Jointed Rock Mass Effects on the Seismic Waves Scattering from the Canyon Sites in the Dam\'s Support

open access: yesعلوم آب و خاک, 2019
Seismic study of canyon sites has always been one of the important fields of seismic studies because of massive structures such as dams that are built in such sites.
M. Zabardast, F. Daneshvar Vousoughi
doaj  

Investigating the Failure Mechanism of Jointed Rock Slopes Based on Discrete Element Method

open access: yesAdvances in Civil Engineering, 2020
This paper presents a comprehensive engineering method to investigate the failure mechanism of the jointed rock slopes. The field geology survey is first carried out to obtain the slope joint data.
Chao Peng   +4 more
doaj   +1 more source

MODELING OF JOINTED ROCK MASSES REINFORCED BY ROCK BOLTS

open access: yesDoboku Gakkai Ronbunshu, 1992
不連続面を有する岩盤の補強にロックボルトは非常に有効である. しかし, その効果を数値解析によってシミュレートしようとする場合, 岩盤をそれと力学的に等価な疑似連続体としてモデル化する従来の方法では, その効果を過小評価することになる. 本ノートでは, まずその原因が岩盤のモデル化にあることを指摘し, 従来の疑似連続体モデルの問題点を明らかにする. つぎに, 不連続面を拘束するロックボルトの効果を明らかにするために実施した室内のモデル実験の結果に基づき, ロックボルトによって補強された岩盤のモデル化に対する一つの考え方を提起する.
Shunsuke SAKURAI, Ikuo KAWASHIMA
openaire   +2 more sources

Hill of Banchory Geothermal Energy Project Feasibility Study Report [PDF]

open access: yes, 2016
This feasibility study explored the potential for a deep geothermal heat project at Hill of Banchory, Aberdeenshire. The geology of the Hill of Fare, to the north of Banchory, gives cause to believe it has good geothermal potential, while the Hill of ...
Feliks, Michael   +11 more
core  

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