Results 41 to 50 of about 316,330 (294)
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Joke construction and joke structure
, 2020 This paper deals with the thorny but fascinating process of (re)constructing jokes, the dynamic process of retelling, which produces a joke structure that is often different from “canonical”. In order to study this, I have exposed a small group of native speakers of Polish and a few native speakers English of both genders to a doctor joke in the ...
openaire +2 more sources
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
The Joke – a(n) (Un)Important Form of Humor
Etnoantropološki Problemi, 2016 The joke is a form of humor that has not received as much attention by Serbian folkloristics and anthropology as it deserves. A possible reason for this is that the joke is so thoroughly incorporated into everyday communication that it tends to be ...
Vesna Trifunović
doaj
Improving selection stability of multiple testing procedures for fMRI [PDF]
, 2010 In search of an appropriate thresholding technique in the analysis of functional MRI-data, several methods to prevent an inflation of false positives have been proposed.
Durnez, Joke, Moerkerke, Beatrijs
core
The use of innovation and practice profiles in the evaluation of curriculum implementation [PDF]
, 1994 Most generic curriculum reform efforts have to deal with a gap between the innovative aspirations of the initial designers and the daily reality of the intended audience of teachers. That tension is not alarming in itself. One might even say that without
Akker, Jan van den, Voogt, Joke
core +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Subtotal hippocampal resection can leave residual hippocampal tissue, yet the immediate postoperative electrophysiologic evolution of such remnants is unknown. We describe a patient with drug‐resistant temporal lobe epilepsy in whom a hippocampal remnant was continuously monitored using a responsive neurostimulator (RNS) following subtotal ...
Patrick Hartnett +5 more
wiley +1 more source
Verbal humor in selected Indonesian stand up comedian’s discourse: Semantic analysis using GVTH
Cogent Arts & Humanities, 2021 Humor is inevitable and can be found in many aspects of human life. In Indonesia, stand-up comedy (SUC) becomes a trend proven by the existence of some talent competitions in this area.
Mulyadi Mulyadi +2 more
doaj +1 more source