Results 91 to 100 of about 240,947 (277)

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

open access: yesAdvanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi   +18 more
wiley   +1 more source

You must be joking! [PDF]

open access: yes, 2015
Are jokes sometimes funnier because they are immoral, wonders Scott ...
Woodcock, Scott
core  

07. Richard Richards is a Gay Scientist [PDF]

open access: yes, 2020
A little recognized and under-appreciated fact about the august Richard Richards is that he is a gay scientist. I know what you may be thinking—Richard’s never shagged dudes, and if he has, it’s shitty to out him in an essay that’s meant to honor him ...
Monroe, David
core   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

open access: yesAdvanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir   +7 more
wiley   +1 more source

Book review: Jonathan Waterlow (2018). It’s Only a Joke, Comrade! Humour, Trust and Everyday Life Under Stalin (1928-1941). Oxford: CreateSpace Independent Publishing Platform.

open access: yesThe European Journal of Humour Research, 2020
The book “It’s only a joke, comrade! Humour, trust and everyday life under Stalin (1928-1941)” is a historiographic study of humour created and used by ordinary Soviet citizens in the pre-war period of the Soviet history. The analysis of multiple sources
Ksenia Shilikhina
doaj  

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

open access: yesAdvanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel   +11 more
wiley   +1 more source

Live From New York, It\u27s the Fake News! Saturday Night Live and the (Non)Politics of Parody [PDF]

open access: yes, 2012
Though Saturday Night Live\u27s “Weekend Update” has become one of the most iconic of fake news programs, it is remarkably unfocused on either satiric critique or parody of particular news conventions.
Day, Amber, Thompson, Ethan
core   +1 more source

5′tRF‐GlyGCC Promotes Breast Cancer Progression via LDHA‐Mediated Glycolysis and Macrophage Polarization

open access: yesAdvanced Science, EarlyView.
5’tRF‐GlyGCC promotes breast cancer malignancy by binding to LDHA. This interaction, facilitated by FGFR1 and LDHA phosphorylation, enhances glycolysis. Additionally, 5’tRF‐GlyGCC/LDHA signaling recruits and polarizes macrophages into a pro‐tumor M2 state via CCL7, thus remodeling the tumor microenvironment.
Cheng Yi   +17 more
wiley   +1 more source

La barzelletta contemporanea (traduzione di Kristina Polakova)

open access: yeseSamizdat, 2023
Italian translation of Sovremennyi anekdot by Aleksandr Belousov.
Aleksandr Belousov
doaj  

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló   +2 more
wiley   +1 more source

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