Results 101 to 110 of about 240,947 (277)
Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation
Advanced Science, EarlyView.A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun +8 more
wiley +1 more source
The European Journal of Humour Research, 2021 A prominent humour theory suggests that most jokes will violate a subjective moral principle. This paper explores the ramifications of Thomas Veatch’s social violations theory of humour, and hypothesizes that jokes tend to produce four distinct humour ...
Joseph Polimeni
doaj
NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, EarlyView.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
, 2013 Some humor is offensive, but does this convey a moral constraint on what comedians can include in their jokes? Using stand up bits and reflections on comedy from George Carlin, Louis C.K., and Doug Stanhope, various philosophies of humor, and the ...
Garrett, James H.
core
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Advanced Science, EarlyView.Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira +18 more
wiley +1 more source
Advanced Science, EarlyView.This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun +8 more
wiley +1 more source
Teaching metalinguistic awareness and reading comprehension with riddles [PDF]
, 2008 The article reports on multiple meanings in sentences and metalinguistic awareness in education. Comprehension of lexical ambiguity and structural ambiguity are presented as key components of reading education.
Zipke, Marcy
core +1 more source
Advanced Science, EarlyView.This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen +10 more
wiley +1 more source
Advanced Science, EarlyView.Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang +8 more
wiley +1 more source
The European Journal of Humour Research, 2018 Book review Gini, Al (2017). The Importance of Being Funny: Why We Need More Jokes in Our Lives. Lanham, Maryland: Rowan and Littlefield. 141 pp.
Jennifer Marra
doaj