Results 61 to 70 of about 24,396 (244)

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

open access: yesAdvanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li   +8 more
wiley   +1 more source

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

open access: yesAdvanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun   +10 more
wiley   +1 more source

Water Jokes [PDF]

open access: yes, 2021
122 unnumbered pages : chiefly color illustrations First Edition of 200, First Printing --colophon. \u27Water Jokes\u27 is a collaboration with lucky risograph for the 2021 Printed Matter Virtual Art Book Fair.
Gallo, Adriana   +2 more
core  

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

open access: yesAdvanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li   +4 more
wiley   +1 more source

Humour Runs through the Multicoloured Mosaic of Neuropsychotherapy: Scoping Review

open access: yesNeurologijos seminarai
Background. The investigation is devoted to explore the possibilities of humour to treat neuropsychiatric disorders which, in the last decade, have significantly increased. The aim of the study is to describe the growing investigations, in which various
M. Šeduikienė, V. Matonis
doaj   +1 more source

REPRESENTASI PEREMPUAN BERAMBUT PIRANG DALAM BLONDE JOKES [PDF]

open access: yes, 2014
This paper is about how blonde women are represented in blonde jokes. Throughout times, blondes are portrayed in two stereotypes: a) they are described as physically and sexually attractive, and b) they are described as brainless, su-perficial, and use ...
Prihhartini, Sya’baningrum
core   +1 more source

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

open access: yesAdvanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li   +13 more
wiley   +1 more source

The Uncopyrightability of Jokes [PDF]

open access: yes, 1998
A joke consists of a setup, a premise, and a punch line. It is likely that jokes can be copyrighted under existing laws. However, several facts leave comedians to protect themselves by private means.
Madison, Allen D.
core  

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

open access: yesAdvanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu   +7 more
wiley   +1 more source

Die grapteks met verwysing na die interessantheidsbeginsel

open access: yesLiterator, 1994
Jokes are special kinds of texts: they do not communicate something about the real, existing world like some other kinds of texts do, because they are worlds in themselves.
P. S. de Bruyn
doaj   +1 more source

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