Results 41 to 50 of about 9,514 (261)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

“Yo mama so fat we had to run TWO studies”

open access: yesThe European Journal of Humour Research
Two studies examine factors associated with reactions to the popular mother joke format (i.e., jokes denigrating or disrespecting the audience’s mother), both in general (Study 1, n = 167 undergraduates, predominantly White) and for specific jokes ...
Andrew R. Olah   +2 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Les comédiens de stand-up et la preuve par le rire : le récit comme acte cognitif dans Star Wars Canteen 1 & 2 d’Eddie Izzard*

open access: yesCahiers de Narratologie, 2015
A stand-up comedian is a person whose action consists in standing on stage to trigger laughter by telling stories. Stand-up comedy can be defined as a performed conversation between a comedian and her audience.
Guillemette Bolens
doaj   +1 more source

Genre and stylistic markers of Ukrainian folk jokes

open access: yesThe European Journal of Humour Research, 2023
This article focuses on the study of Ukrainian social and domestic folk jokes that contain information about the life of people, their habits, customs, traditions, and relations, and ridicule the weak sides of Ukrainians. The research material comprises
Olena Yemelyanova   +2 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Joke construction and joke structure

open access: yes, 2020
This paper deals with the thorny but fascinating process of (re)constructing jokes, the dynamic process of retelling, which produces a joke structure that is often different from “canonical”. In order to study this, I have exposed a small group of native speakers of Polish and a few native speakers English of both genders to a doctor joke in the ...
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

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