Results 271 to 280 of about 7,204,095 (323)
The Chemistry and Biology of the Tetrodotoxin Natural Product Family
Angewandte Chemie International Edition, Accepted Article.Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity.
Benedikt Nißl +6 more
wiley +1 more source
Current views and implications of journal impact factor: A key note.
South Asian J Cancer, 2016 Zaidi I, Singh S, Sinha A, Dwivedi R.
europepmc +1 more source
Efficient Red Light‐Driven Singlet Oxygen Photocatalysis with an Osmium‐Based Coulombic Dyad
Angewandte Chemie International Edition, Accepted Article.Photoactive osmium complexes are widely used sensitizers for the generation of singlet oxygen, because they can be excited directly into their triplet states with low‐energy red light. However, their short‐lived excited states reduce quenching efficiencies and reaction quantum yields significantly.
Matthias Schmitz +3 more
wiley +1 more source
Amide Chemistry Enables Redox Locking of Cyclic Disulfides for Polypeptide Assembly
Angewandte Chemie International Edition, Accepted Article.A practical strategy in synthetic organic chemistry for shutting down temporarily the nucleophilicity of thiols is to exploit their redox properties by converting them into disulfides. The stability of such a thiol protection in reductive medium can be sensitive to microenvironmental changes, including chemical modifications occurring nearby.
Vincent Diemer +4 more
wiley +1 more source
Angewandte Chemie International Edition, Accepted Article.This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley +1 more source
Angewandte Chemie International Edition, EarlyView.The cobalt complexes [(Hbbpya)CoII]2⁺, and [(Mebbpya)CoII]2⁺ show contrasting CO₂ reduction behaviors. [(Hbbpya)CoII]2⁺ selectively forms CO via a fast, two‐electron pathway aided by a ‐NH proton relay, while [(Mebbpya)CoII]2⁺ favours hydrogen evolution due to a slower, competitive one‐electron mechanism.
Ayan Bera +13 more
wiley +1 more source
A Phenomenological Symmetry Rule for Chemical Reactivity under Vibrational Strong Coupling
Angewandte Chemie International Edition, Accepted Article.Symmetry is known to strongly influence the course of a chemical reaction. It has also been found to play a key role in vibrational strong coupling (VSC), where it can influence the outcome of chemical reactions or alter chemical equilibria. However, the precise nature of this effect and its extent remains elusive.
Anjali Jayachandran +8 more
wiley +1 more source
Building a Bridge Between Ambient MS and LC‐MS by Non‐Exhaustive Microdesorption
Angewandte Chemie International Edition, Accepted Article.Ambient mass spectrometry (AMS) offers rapid screening but faces challenges in analyzing complex samples due to high matrix effects and limited selectivity. The absence of a separation step can also lead to false positives due to the isomers or isobars.
Wei Zhou, Janusz Pawliszyn
wiley +1 more source
Mechanoactivated Celite as a catalyst for C‒H bond perfluoroalkylation and other radical reactions
Angewandte Chemie International Edition, Accepted Article.Herein we report that Celite (diatomaceous earth) commonly viewed as an innocent filter aid or support material, or Earth‐abundant, non‐toxic metal oxides are efficient mechanoactivated catalysts for arene and heteroarene C‒H bond radical trifluoromethylation and pentafluoroethylation, with the activity comparable with previously reported ...
Thomas J. Hasiweder +4 more
wiley +1 more source