Results 31 to 40 of about 183,080 (139)

Viral Pathogens Threatening Cage‐Cultured Nile Tilapia in Lake Victoria: Epidemiology, Emerging Risks and Integrated Health Management Strategies

open access: yesAquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.
ABSTRACT The rapid expansion of cage culture for Nile tilapia (Oreochromis niloticus) in Lake Victoria is central to food security and profitable development in East Africa. Nevertheless, viral conditions affect the sustainability of this sector, with significant imbalances in livelihood, trade and aquaculture adaptability.
Richard S. Komba, Chacha J. Mwita
wiley   +1 more source

T Cell O‐GlcNAcylation Increases in Patients With Allergic Rhinitis After the Natural Pollen Season

open access: yes
Clinical &Experimental Allergy, EarlyView.
Eduardo I. Cardenas   +7 more
wiley   +1 more source

Decoding Aquaculture's Future: A Review of Molecular Docking and Simulation in Enhancing Growth and Disease Resistance

open access: yesAquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.
ABSTRACT Aquaculture has overtaken capture fisheries as the main source of aquatic animal protein, marking a critical step in global food security. Yet, rapid intensification faces major challenges, including disease outbreaks, environmental degradation, and dependence on wild‐caught fish for feed.
Suvadip Ghara   +8 more
wiley   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

open access: yesAdvanced Intelligent Discovery, Volume 2, Issue 3, June 2026.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan   +3 more
wiley   +1 more source

Lysine lactylation‐mediated post‐translational modification: Molecular mechanisms and therapeutic target exploration in tumour drug resistance

open access: yesClinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Lysine lactylation (Kla) serves as a metabolic–epigenetic switch governed by writer–eraser–reader regulatory systems, directly connecting the Warburg effect to diverse forms of tumour drug resistance. Intratumoural lactylation critically contributes to treatment failure in chemotherapy, targeted therapy and immunotherapy.
Juan Li   +5 more
wiley   +1 more source

Cardioprotective effect of spirulina on cafeteria diet‐induced cardiac injury in silico and in vivo study

open access: yesJournal of the Science of Food and Agriculture, Volume 106, Issue 8, Page 4720-4743, June 2026.
Abstract BACKGROUND Obesity is a major risk factor for cardiovascular disease, primarily due to its effects on lipid metabolism, oxidative stress, and inflammation. The aim of this study was to evaluate the effects of spirulina (SP) on cafeteria diet (CD)‐induced myocardial oxidative stress and inflammation using biochemical, histological, and in ...
Fatma Arrari   +3 more
wiley   +1 more source

Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors

open access: yesActa Crystallographica Section F, Volume 82, Issue 6, Page 201-207, June 2026.
The crystal structure of the human orexin type 2 receptor–vornorexant complex (3.29 Å resolution) and orexin type 1 receptor docking revealed a conserved U‐shaped binding conformation, explaining the high affinity and balanced dual antagonism of this dual orexin receptor antagonist. The structural data validate the rational design that incorporated a 1,
Masashi Mima   +4 more
wiley   +1 more source

Crystal structure of Plasmodium vivax macrophage migration inhibitory factor

open access: yesActa Crystallographica Section F, Volume 82, Issue 6, Page 194-200, June 2026.
The production, crystallization and 1.8 Å resolution crystal structure of macrophage migratory inhibitory factor from P. vivax are reported.Plasmodium vivax is a major cause of malaria globally and has recently been transmitted locally in the USA. P. vivax produces homologs of host proteins, including cytokines such as macrophage migration inhibitory ...
Aryana Nair   +11 more
wiley   +1 more source

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

open access: yesActa Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik   +44 more
wiley   +1 more source

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