Results 41 to 50 of about 183,080 (139)

Single‐Cell Analysis Identifies LYPD6B as a Tumor‐Intrinsic Candidate Associated With Immunotherapy Nonresponse in Breast Cancer

Thoracic Cancer, Volume 17, Issue 11, June 2026.
LYPD6B is a tumor‐intrinsic mediator of immune evasion and resistance to PD‐(L)1 therapy in breast cancer; targeting LYPD6B may improve immunotherapy efficacy. ABSTRACT Immune checkpoint blockade (ICB) induces durable responses in a subset of breast cancer patients, yet many show limited benefit from anti‐PD‐1/PD‐L1 therapy.
Yifei Wang, Haiwei Quan, Zhiguang Xu, Yixiang Wang, Zhibin Wang   +4 more
wiley   +1 more source

Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21‐ and OTUD4‐mediated EZH2 ubiquitination

British Journal of Pharmacology, Volume 183, Issue 11, Page 2675-2694, June 2026.
Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng, Yuanjun Tang, Xuedi Cao, Xiaotong Yu, Zhanya Huang, Yunyun Guo, Renjing Jin, Yan Wang, Yang Liu, Lixiang Xue, Yuqing Wang   +10 more
wiley   +1 more source

Second‐generation prokineticin PKR1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity

British Journal of Pharmacology, Volume 183, Issue 12, Page 3377-3394, June 2026.
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand, Simone Brogi, Mustafa Tezeren, Andrea Tafi, Omer H. Ocak, Hasan Koyuncu, Igor Tetko, Laurent Désaubry, Canan G. Nebigil   +8 more
wiley   +1 more source

From plant to fabric: Environmental opportunities associated with annatto dye for sustainable development in the textile industry

Coloration Technology, Volume 142, Issue 3, Page 333-353, June 2026.
Abstract Natural dyes are compounds that occur naturally in several organisms and are classified based on chemical structure and application method. The literature cites several natural dyes used in industrial transformation processes. Annatto dye is used in the food industry, and its biological pigment is extracted from the annatto seed. However, this
Marcel Jefferson Gonçalves, Tania Maria Costa, Karine Thaise Rainert, Vera Lúcia Vogel Faustino dos Santos, Ivonete Oliveira Barcellos, Lorena Benathar Ballod Tavares   +5 more
wiley   +1 more source

A role for core facilities in improving research rigour

Journal of Microscopy, Volume 302, Issue 3, Page 256-266, June 2026.
Abstract Scientific reproducibility is an ethical and societal responsibility. Discussions of reproducibility and repeatability often focus on the roles of stakeholders in the scientific process, including researchers, publishers, and funders. Core facility staff have distinct functions in research planning, training, interpretation and oversight which
Alison J. North, Kurt I. Anderson
wiley   +1 more source

The BAHD Acyltransferase Gene Family: Evolutionary Dynamics, Biochemical Mechanisms, and Roles in Plant Stress Adaptation

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4139-4158, June 2026.
BAHD acyltransferases drive metabolic diversification in plants by coupling conserved catalytic scaffolds with regulatory flexibility, enabling stress adaptation and ecological specialisation. ABSTRACT BAHD acyltransferases constitute one of the most versatile enzyme superfamilies in plants, catalysing the acylation of alcohols, amines, polyamines, and
Muhammad Mubashar Zafar, Qiao Fei, Abdul Razzaq, Ayesha Siddiqua, Ayesha Naveed, M. Nasir Khan, Huma Saleem, Xuefei Jiang   +7 more
wiley   +1 more source

Erratum to “Kinetics and molecular docking of vasicine from Adhatoda vasica: An acetylcholinesterase inhibitor for Alzheimer's disease” [South African journal of botany 104C (2016) 118–124]

South African Journal of Botany, 2017
S.K. Ali, A.R. Hamed, M.M. Soltan, A.M. El-Halawany, U.M. Hegazy, A.A. Hussein   +5 more
openaire   +1 more source

Reproducibility, validation, and failure modes across classical and AI-driven molecular docking. [PDF]

J Comput Aided Mol Des
Kittelson KS, Martins ACF, Santos RP, Celante G, da Silva Gomes R.   +4 more
europepmc   +1 more source

Fungal <i>Cordyceps</i> Nucleosides and Analogs as Potential Anti-Glioblastoma PD-L1 Inhibitors: An In Silico Multiparameter Optimization (MPO) Design. [PDF]

Int J Mol Sci
Muñoz-González F, Bello M, Correa-Basurto J, Bandala C.   +3 more
europepmc   +1 more source

Deep docking, part 2: an amplified DDU platform for ultra-large virtual screening. [PDF]

Chem Sci
Pandey M, Sajed T, Semenov I, Zhang R, Ban F, Manskaia E, Ester M, Cherkasov A.   +7 more
europepmc   +1 more source