Bacteriome analysis of Aggregatibacter actinomycetemcomitans-JP2 genotype-associated Grade C periodontitis in Moroccan adolescents [PDF]
Frontiers in Oral Health, 2023 BackgroundGrade C (previously aggressive) periodontitis (GCP) in adolescents is prevalent in certain parts of Africa where it is associated with JP2 genotype, a highly virulent strain of Aggregatibacter actinomycetemcomitans. The aim of this study was to
Vijaya Lakshmi Pavani Molli +6 more
doaj +7 more sources
Discrepancies in Antimicrobial Susceptibility between the JP2 and the Non-JP2 Genotype of Aggregatibacter actinomycetemcomitans [PDF]
Antibiotics, 2022 The Aggregatibacter actinomycetemcomitans JP2 genotype is associated with high leukotoxin production and severe (aggressive) periodontitis. The aim of this study was to compare the antimicrobial susceptibility of JP2 and non-JP2 genotype strains. Minimal
Margareta Granlund +3 more
doaj +6 more sources
JP2 Genotype of Aggregatibacter actinomycetemcomitans in Caucasian Patients: A Presentation of Two Cases [PDF]
Pathogens, 2020 Aggregatibacter actinomycetemcomitans is a key pathogen that has been associated with periodontal disease. Its most important virulence factor is a leukotoxin capable of inactivating immune cells. The JP2 genotype of Aggregatibacter actinomycetemcomitans
Alexandra Stähli +2 more
doaj +6 more sources
Carriage of the JP2 Genotype of Aggregatibacter actinomycetemcomitans by Periodontitis Patients of Various Geographic Origin, Living in Sweden [PDF]
Pathogens, 2022 The JP2 genotype of Aggregatibacter actinomycetemcomitans serotype b is associated with aggressive forms of periodontitis and was initially identified as affecting adolescents in North and West Africa.
Rolf Claesson +2 more
doaj +5 more sources
The Highly Leukotoxic JP2 Genotype of Aggregatibacter actinomycetemcomitans Is Present in the Population of the West African Island, Sal in Cape Verde: A Pilot Study [PDF]
Pathogens, 2022 Aggregatibacter actinomycetemcomitans is strongly associated with severe periodontitis, possibly due to its production of a potent leukotoxin. A genetic variant, the JP2 genotype, was found to produce more leukotoxin than the wild type because of a ...
Johannes J. De Soet +5 more
doaj +8 more sources
Differential Cell Lysis Among Periodontal Strains of JP2 and Non-JP2 Genotype of Aggregatibacter actinomycetemcomitans Serotype B Is Not Reflected in Dissimilar Expression and Production of Leukotoxin [PDF]
Pathogens, 2019 Leukotoxic potential of Aggregatibacter actinomycetemcomitans strains has been studied by the use of several methods, and results differ depending on the methods used.
Anne Birkeholm Jensen +6 more
doaj +6 more sources
Multilocus sequence typing (MLST) of JP2 genotype isolates of Aggregatibacter actinomycetemcomitans collected from carriers of African and non-African origin [PDF]
Journal of Oral Microbiology, 2017 The bacterium Aggregatibacter actinomycetemcomitans is associated with aggressive periodontitis. Individuals colonised with the highly leukotoxic JP2 genotype of the bacterium, are at increased risk for developing periodontitis.
Rolf Claesson +3 more
doaj +4 more sources
Multilocus Sequence Typing of Aggregatibacter actinomycetemcomitans Competently Depicts the Population Structure of the Species [PDF]
Microbiology Spectrum, 2021 We developed a multilocus sequence typing scheme (MLST) for Aggregatibacter actinomycetemcomitans based on seven housekeeping genes, adk, atpG, frdB, mdh, pgi, recA, and zwf. A total of 188 strains of seven serotypes were separated into 57 sequence types.
Signe Nedergaard +3 more
doaj +5 more sources
Aggregatibacter actinomycetemcomitans and Filifactor alocis as Associated with Periodontal Attachment Loss in a Cohort of Ghanaian Adolescents [PDF]
Microorganisms, 2022 The aims of the present study were to document the presence of Aggregatibacter actinomyctemcomitans and the emerging oral pathogen Filifactor alocis, as well as to identify genotypes of these bacterial species with enhanced virulence.
Zeinab Razooqi +6 more
doaj +2 more sources
Multilocus Sequence Typing of Non-JP2 Serotype b Aggregatibacter actinomycetemcomitans Strains of Ghanaian and Swedish Origin [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Objective and MethodsThe Gram-negative bacterium, Aggregatibacter actinomycetemcomitans is associated with periodontitis affecting young individuals. The geographic dissemination of the highly leukotoxic JP2 genotype of serotype b of this species was ...
Rolf Claesson +5 more
doaj +2 more sources