Results 1 to 10 of about 13,074 (114)
The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis
Tissue Engineering and Regenerative Medicine, 2021 BACKGROUND: Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are
Mikyung Kang, Mungyo Jung, Ok Hee Jeon
exaly +2 more sources
ACS Medicinal Chemistry LettersThe bromodomain inhibitor (+)-JQ1 is a highly validated chemical probe; however, it exhibits poor in vivo pharmacokinetics. To guide efforts toward improving its pharmacological properties, we identified the (+)-JQ1 primary metabolite using chemical ...
Kenneth B Guzman RodrÃguez +2 more
exaly +3 more sources
Protective effect of the BET protein inhibitor JQ1 in cisplatin-induced nephrotoxicity
American Journal of Physiology - Renal Physiology, 2018 As a potent chemotherapy drug, cisplatin is also notorious for its side-effects including nephrotoxicity in kidneys, presenting a pressing need to identify renoprotective agents.
Liping Sun +2 more
exaly +2 more sources
Cancer Medicine, 2019 Aim JQ1, a BET bromodomain inhibitor, is a promising therapeutic approach for bladder cancer (BC). Our study aimed to determine whether autophagy is induced by JQ1 and its potential role toward proliferation in BC.
Jianbin Ma, Tie Chong
exaly +2 more sources
Probing BRD inhibition substituent effects in bulky analogues of (+)-JQ1 [PDF]
, 2021 A series of bulky organometallic and organic analogues of the bromodomain (BRD) inhibitor (+)-JQ1 have been prepared. The most potent, N-[(adamantan-1-yl)methyl]-2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,6 ...
Joshua Csucker (9444372) +14 more
core +2 more sources
Front Matter JKAP (Jurnal Kebijakan dan Administrasi Publik)
JKAP (Jurnal Kebijakan dan Administrasi Publik), 2018 Front Matter JKAP (Jurnal Kebijakan dan Administrasi Publik)
Haening Ratna Sumiar
doaj +3 more sources
Manajemen Pengembangan Sagu Di Kampung Simporo Distrik Ebungfauw Kabupaten Jayapura
JAKP (Jurnal Administrasi dan Kebijakan Publik), 2022 Pengembangan ekonomi masyarakat pengolah sagu masih jalan di tempat. Kreasi dalam pengolahan dan pola konsumsi masyarakat menjadi permasalahan yang harus dipecahkan.
Muhammad Ismail Muhammad Ismail
doaj +1 more source
, 2023 The top 10 common genes upregulated or downregulated from 009P1-, 009P2-, (+)-JQ1- and SAHA-treated BCBL-1 cells.
Tran Phuc (3948350) +10 more
core +1 more source
Upaya Pengembangan Inovasi Melalui Jaringan Inovasi Pelayanan Publik
JAKP (Jurnal Administrasi dan Kebijakan Publik), 2022 The Public Service Innovation Network is a form of cooperation in the development of public service innovations that are run between related agencies, as an effort so that all parties are connected to each other in the development of public service ...
Haerana Haerana +3 more
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Analisis Kebijakan Kewirausahaan Nasional Di Metaverse
JAKP (Jurnal Administrasi dan Kebijakan Publik), 2022 Metaverse as a digital phenomenon has had an impact on global life since the Covid-19 pandemic took place. Almost all countries experienced disruption in various sectors. One of the countries undergoing transformation is Indonesia.
Abdurrofi Abdullah Azzam
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