Results 91 to 100 of about 13,977 (118)

Supplementary Figures S1-S5 and Legends from AMPK–ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells

, 2017
Supplementary figure S1. Differential sensitivity of human AML LSCs to JQ1. Supplementary figure S2. Relative levels of the autophagy pathway effectors LC3-II, beclin-1, and pULK1 (S555). Supplementary figure S3. Autophagy induction in KG1 and KG1a cells
Ji Eun Jang (8135850), Ju-In Eom (519760), Yoo Hong Min (8717373), June-Won Cheong (519759), Jung Yeon Lee (12355078), Jin Seok Kim (8717370), Hoi-Kyung Jeung (519761)   +6 more
core   +1 more source

Cover and Editor

Jurnal Natapraja: Kajian Ilmu Administrasi Negara, 2020
Pandhu Yuanjaya
doaj   +3 more sources

Linked collectors and determiners for: Systematics of the Ameerega rubriventris complex (Anura: Dendrobatidae) with descriptions of two new cryptic species from the East-Andean versant of Peru.

Natural history specimen data linked to collectors and determiners held within, "Systematics of the Ameerega rubriventris complex (Anura: Dendrobatidae) with descriptions of two new cryptic species from the East-Andean versant of Peru".
Bionomia
core   +1 more source

The MYC-independent effects of BET inhibitor JQ1 on super-enhancers in cancer

, 2019
MYC overexpression plays an important role in cancer progression and is a common feature of many cancer types. One reason is due to the invasion of super-enhancer regions by MYC upstream of oncogenes, often resulting in activation of oncogenic pathways ...
Chia, Boon Jun
core  

Epigenetic regulation in cancer. [PDF]

MedComm (2020)
Gu M, Ren B, Fang Y, Ren J, Liu X, Wang X, Zhou F, Xiao R, Luo X, You L, Zhao Y.   +10 more
europepmc   +1 more source

Unlocking the "undruggable": current landscape and emerging frontiers in lysosomal receptor-mediated protein degradation. [PDF]

Drug Deliv
Ma YM, Xia HF, Xiao YL, Yu ZL.
europepmc   +1 more source

Bromodomain Inhibitor JQ1 Modulates Collagen Processing and Ameliorates Bleomycin Induced Dermal Fibrosis in Mice

, 2014
Background/Purpose: Systemic sclerosis (SSc) is a complex pro-inflammatory scarring disease, characterised by elevated deposition of extracellular matrix (ECM) proteins, in particular collagen type I.
Holmes, A, Trinder, S, Shi-Wen, X, Abraham, D, Gilbane, A, Good, A, Tarriela, M   +6 more
core  

Cover and Editor

Jurnal Natapraja: Kajian Ilmu Administrasi Negara, 2017
Pandhu Yuanjaya
doaj   +1 more source

The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis

Tissue Engineering and Regenerative Medicine, 2021
BACKGROUND: Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are
Kim Byung-Soo, Mungyo Jung, Mikyung Kang   +2 more
exaly   +2 more sources

Colorectal cancer inhibition by BET inhibitor JQ1 is MYC-independent and not improved by nanoencapsulation

European Journal of Pharmaceutics and Biopharmaceutics, 2022
Bromodomain and extraterminal domain protein inhibitors (BETi) for cancer treatment did not convince during their first clinical trials. Their epigenetic mechanism of action is still not well understood, even if MYC is generally considered as its main ...
Simo Schwartz, Véronique Préat, Valentina Maggio   +2 more
exaly   +2 more sources