Results 121 to 130 of about 670,170 (347)

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

Agency in the Alternatives: Common-Law Perspectives on Binding the Firm [PDF]

, 2014
This chapter in a forthcoming book examines the external aspects of agency law in the context of unincorporated firms, that is, the capacity of actors associated a firm to bind it to the legal consequences of interactions with third parties.
Mörrby, Johan, Partin, Patrik
core   +1 more source

The Consumer Scam: An Agency-Theoretic Approach

, 2019
Despite the extensive body of literature that aims to explain the phenomenon of consumer scams, the structure of information in scam relationships remains relatively understudied.
S. Pouryousefi, Jeff Frooman
semanticscholar   +1 more source

Rapid and Direct Detection of Methamphetamine in Biofluids using a MXene‐Enabled Electrochemical Sensor

Advanced Science, EarlyView.
A MXene‐enhanced electrochemical sensor enables the rapid and direct detection of methamphetamine. Molecular simulations reveal that specific MXene surface functional groups act as key signal amplifiers by facilitating interfacial interactions. The sensor demonstrates high sensitivity and robust performance in complex biological matrices.
Ri Wang, Xiaofei Deng, Bo Chen, Jienan Shen, Wei Xu, Yingjie Zhu, Yi Zhang, Hui Yang   +7 more
wiley   +1 more source

Building Trust Through Feedback: A Conceptual Framework for Educators

Teaching & Learning Inquiry: The ISSOTL Journal
Trust is fundamental for effective student engagement with feedback in higher education. This study aimed to develop a conceptual framework delineating the specific instructor practices and learning environment conditions that facilitate trustful ...
Breana Bayraktar, Kiruthika Ragupathi, Katherine A. Troyer   +2 more
doaj   +1 more source

Neural Network‐Based Permittivity Engineering of Magnetic Absorbers for Customizable Microwave Absorption

Advanced Science, EarlyView.
A neural network‐enabled permittivity engineering paradigm is introduced, transcending traditional trial‐and‐error design. By decoupling electromagnetic parameters and screening a high‐throughput feature space, an ultrathin (1.0 mm) magnetic absorber is inversely designed, experimentally achieving a superior and customizable 5.1 GHz bandwidth and ...
Chenxi Liu, Jinzhe Li, Sen Li, Zhongqiu Guo, Yao Chen, Tian Li, Renchi Qin, Jiaxu Sun, Yongxi Lu, Fanbin Meng   +9 more
wiley   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Brokering a Difficult Marriage: Substantive Defenses under Rule 60(b)(4) Relief from Default Judgments in Foreign Sovereign Immunities Act Proceedings [PDF]

, 1990
This Note argues that U.S. courts should allow foreign states to raise substantive defenses when using Rule 60(b)(4) to challenge the courts\u27 jurisdiction to enter a default judg- ment.
Sutham, A. John
core   +1 more source

Perceived mental illness is associated with judgments of less agency, yet more moral wrongness

Possibility Studies & Society
For a set of 10 conditions (e.g. homosexuality, obesity, drug addiction), we explored associations between moral judgments, agency evaluations, and perceptions that a condition is a mental illness. In a preregistered study ( n = 1,249 U.S. adults), we found that perceptions of lower agency were associated with decreased moral wrongness judgments, as ...
Charul Maheshka, Meriel Doyle, Brett Mercier, Azim Shariff, Cory J. Clark   +4 more
openaire   +1 more source

How AI Shapes the Future Landscape of Sustainable Building Design With Climate Change Challenges?

Advanced Science, EarlyView.
This review examines how artificial intelligence reshapes sustainable building design faced with climate change challenges. The authors synthesize existing studies to demonstrate AI's transformative potential across design lifecycle phases from climate‐aware form generation to performance optimization.
Pengyuan Shen, Xiaoni Gao, Shuai Lu, Yi Zhang, Xing Zheng, Matthaios Santamouris   +5 more
wiley   +1 more source