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Cytotoxicity of juglone and thymoquinone against pancreatic cancer cells
Chemico-Biological Interactions, 2020 Juglone and thymoquinone are cytotoxic to pancreatic cancer cells. The aim of this study was to investigate, using an analysis of isobolograms, the type and degree of interactions between juglone and thymoquinone on MIA PaCa-2 pancreatic cancer cells ...
Jack Losso
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Addition of Hydrogen Sulfide to Juglone
Environmental Science & Technology, 2002Evidence of the addition of hydrogen sulfide to 5-hydroxy-1,4-naphthoquinone (juglone) in aqueous solution was obtained by nuclear magnetic resonance spectrometry (NMR), electron paramagnetic resonance spectrometry (EPR), UV-visible absorbance spectroscopy, and kinetic measurements.
Perlinger, J.A. +3 more
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Effects of intravenous juglone in the dog
Toxicon, 1968Abstract Juglone, 5-hydroxy, 1:4 naphthoquinone, a natural product of the black walnut, Juglans nigra , was dissolved in an ethanol-glucose mixture and injected i.v. into anesthetized dogs. It produced no changes in EKG, heart rate, or blood pressure.
J N, Boelkins, L K, Everson, T K, Auyong
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Journal of Chemical Education, 1973
It is well established that the black walnut tree and the tomato plant are involved allelopathically and that juglone is the active principle.
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It is well established that the black walnut tree and the tomato plant are involved allelopathically and that juglone is the active principle.
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Pharmacological aspects of juglone
Toxicon, 1963Abstract Juglone (5-hydroxy, 1-4 naphthoquinone), isolated from Juglans nigra (Black Walnut) in pure crystalline form has been investigated pharmacologically. These studies indicate that juglone is a depressant agent to unanesthetized fish, mice, rats and rabbits. It dilates the ear vessels of the intact rabbit and coronary arteries of the isolated
T.K. Auyong, B.A. Westfall, R.L. Russell
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Antimicrobial activity of juglone
Phytotherapy Research, 1990AbstractThe juice of freshly macerated unripe hulls of the black walnut (Juglans nigra) has been used for many years in folk medicine as a treatment for localized, topical fungal infections such as ringworm. It has been proposed that the biological activity of the walnut hulls is due to the presence of the simple naphthoquinone, juglone (5‐hydroxy‐1,4 ...
Alice M. Clark +2 more
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Journal of Chemical Education, 1976
Because Juglone is allelopathic, its preparation provides a relevant exercise in synthetic organic chemistry for undergraduates studying biological sciences.
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Because Juglone is allelopathic, its preparation provides a relevant exercise in synthetic organic chemistry for undergraduates studying biological sciences.
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Enhanced Eryptosis Following Juglone Exposure
Basic & Clinical Pharmacology & Toxicology, 2014AbstractJuglone, a quinone isolated from Juglans mandshurica Maxim, has previously been shown to be effective against malignancy. The effect is at least partially due to stimulation of suicidal death or apoptosis of tumour cells. On the other hand, juglone has been shown to counteract apoptosis, for example, of neurons.
CALABRÒ S. +5 more
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Degradation of juglone by soil bacteria
Journal of Chemical Ecology, 1988Bacteria that can degrade juglone (5-hydroxy-1,4-naphthoquinone) were isolated from soil beneath black walnut trees. Autecological studies with one of these bacteria (Pseudomonas J1), demonstrated that it could grow rapidly using juglone as its sole source of carbon and energy.
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