Juglone in Oxidative Stress and Cell Signaling [PDF]
Antioxidants, 2019 Juglone (5-hydroxyl-1,4-naphthoquinone) is a phenolic compound found in walnuts. Because of the antioxidant capacities of phenolic compounds, juglone may serve to combat oxidative stress, thereby protecting against the development of various diseases and
Yuichiro J Suzuki, Taseer Ahmad
exaly +6 more sources
Juglone Protects Against CLP-Induced Sepsis by Regulating Apoptosis, Pyroptosis, and Oxidative Stress Mechanisms [PDF]
PharmaceuticalsBackground: Sepsis is a life-threatening systemic condition characterized by organ dysfunction resulting from a dysregulated host response to infection.
Ömer Faruk Başer, Mahmut Karapehlivan
doaj +3 more sources
Is Juglone the Only Naphthoquinone in Juglans regia L. with Allelopathic Effects?
Agriculture, 2021 We investigated whether juglone is the only allelochemical in a leaf extract from the walnut (Juglans regia L.). This was achieved through comparisons of the effects of pure juglone (1 mM, 100 μM, 10 μM control juglone) and J.
Aljaz Medic +4 more
doaj +2 more sources
Juglone as antihypertensive agent acts through multiple vascular mechanisms
Clinical and Experimental Hypertension, 2020 Background: Juglone, a natural phenolic compound obtained from the walnut tree, is known for its wide range of biological activities. However, it has yet to be tested for its effects on hypertension and vascular tone.
Taseer Ahmad +3 more
doaj +2 more sources
Juglone Inhibits Listeria monocytogenes ATCC 19115 by Targeting Cell Membrane and Protein
Foods, 2022 Foodborne disease caused by Listeria monocytogenes is a major global food safety problem. A potential solution is the antimicrobial development of the highly bioactive natural product juglone, yet few studies exist on its antibacterial mechanism against ...
Yingying Cai +8 more
doaj +2 more sources
Modulation of Apoptosis and Autophagy by Melatonin in Juglone-Exposed Bovine Oocytes
Animals, 2023 Melatonin, an antioxidant hormone secreted by the pineal gland, has been recognized as a regulator for numerous biological events. The deleterious effects of juglone, a polyphenolic extract of walnut trees, on embryo development has been previously ...
Marwa El-Sheikh +7 more
doaj +2 more sources
Actions of juglone on energy metabolism in the rat liver [PDF]
Toxicology and Applied Pharmacology, 2011 Juglone is a phenolic compound used in popular medicine as a phytotherapic to treat inflammatory and infectious diseases. However, it also acts as an uncoupler of oxidative phosphorylation in isolated liver mitochondria and, thus, may interfere with the hepatic energy metabolism. The purpose of this work was to evaluate the effect of juglone on several
Saling, Simoni Cristina +4 more
openaire +3 more sources
Targeted juglone blocks the invasion and metastasis of HPV-positive cervical cancer cells
Journal of Pharmacological Sciences, 2019 Human papillomaviruses (HPVs), for instance, HPV 16 and HPV 18, are concerned associated with cervical cancer. Thus, it is essential to suppress HPVs-in HPV-positive cervical cancer for treating cervical cancer.
Xingyu Zhao +6 more
doaj +2 more sources
Herbicidal effects of juglone as an allelochemical
, 2007 Juglone is a natural constituent of walnut with phytotoxic and allelopathic properties. Its herbicidal effects on the weed species wild mustard (Sinapis arvensis L.), creeping thistle (Cirsium arvense L.), field poppy (Papaver rhoeas L.) and henbit (Lamium amplexicaule L.) were investigated using wheat (Triticum vulgare Vill. cv.
Topal, Süleyman +3 more
core +6 more sources
Juglone Suppresses LPS-induced Inflammatory Responses and NLRP3 Activation in Macrophages
Molecules, 2020 The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome has been implicated in a variety of diseases, including atherosclerosis, neurodegenerative diseases, and infectious diseases.
Nam-Hun Kim +9 more
doaj +2 more sources