Results 21 to 30 of about 3,431 (206)

Juglone induces GSDME axis pyroptosis in osteosarcoma cells via the JNK/P38 MAPK pathway [PDF]

Scientific Reports
The MAPK signaling pathway plays a considerable role in cancer inhibition, and pyroptosis is a type of programmed cell death (PCD); thus, it is essential for cellular activity and cancer progression.
Jierui Zhao, Xingyu Zhao, Yue Lu, He Wang, Yuhan Zhang, Yi Wang, LiChun Xing, Yumiao Guo, Peng Peng, Wei Zhang, Qibiao Wu   +10 more
doaj   +2 more sources

Degradation of juglone by Pleurotus sajor-caju

Mycological Research, 2004
The toxic naphthoquinone juglone (5-hydroxy-1,4-naphthoquinone) is efficiently degraded by the ligninolytic fungus Pleurotus sajor-caju, as demonstrated by the total bleaching within 9 d of a conventional liquid culture medium supplemented with 0.6 mM juglone.
CURRELI, NICOLETTA, RESCIGNO, ANTONIO, Rinaldi A, Pisu B, Sollai F, SANJUST, ENRICO   +5 more
openaire   +4 more sources

Synthesis of Juglone and its Derivatives

Applied Mechanics and Materials, 2011
Juglone (1), plumbagin (2) and isoplumbagin (3) were synthesized from the natural product 4,8-dihydroxy naphthol-β-D-glucoside (4) which existed large amount in barks of Juglans mandshurica. Juglone was achieved directly by deglycosylation catalyzing with CAS in 78 % yield.
Jin Lan Wang, Zhong Jin Yang, Jian Jun Wang, Wan Xia Tang, Ming Zhao, Shu Jun Zhang   +5 more
openaire   +2 more sources

Antimicrobial activity and possible mechanisms of juglone against Escherichia coli, Staphylococcus aureus, and Salmonella pullorum [PDF]

BMC Microbiology
Background Escherichia coli, Staphylococcus aureus, and Salmonella pullorum are significant pathogens that threaten livestock and poultry health. Although antibiotics and synthetic antimicrobial agents can combat these pathogens, antibiotic resistance ...
Lei Wang, Mingxin Qiu, Xuanyue Li, Mengjian Liu, Luyu Li, Yong Chen   +5 more
doaj   +2 more sources

Targeted anticancer effects of Juglone-ZnO nanoparticles via cell cycle arrest and caspase-mediated apoptosis in colon cancer cells [PDF]

Scientific Reports
Finding new drugs for adjuvant chemotherapy of colon cancer is of high priority. This study aimed to evaluate the antiproliferative properties and anticancer mechanisms of glucose (C) functionalized and juglone-conjugated zinc oxide (ZnO) nanoparticles ...
Amin Safa, Mina Shafiei, Arash Norouzpour Sangari, Asal Norouzi Roudbordeh, Fatemeh Ghaderibarmi, Mahdis Kohsarian, Reza Mohaghegh, Zahra Maleki Maaf, Mohadeseh Emamdoost Valisaraei, Zeinab Faraji, Ali Salehzadeh   +10 more
doaj   +2 more sources

TP53 Is a Potential Target of Juglone Against Colorectal Cancer: Based on a Combination of Molecular Docking, Molecular Dynamics Simulation, and In Vitro Experiments [PDF]

Current Issues in Molecular Biology
Background: Colorectal cancer is the third most common cancer worldwide, accounting for about 10% of all cancer cases. There is an urgent need to improve treatment outcomes and survival rates for colorectal cancer.
Yunting Deng, Yanan Zhang, Xinghai Chen, Weiming Wang, Jinhai Huo   +4 more
doaj   +2 more sources

Synthesis and Characterization of Juglone-Derived cu (II), Mn (II) and Zn (II) Complexes and Investigation of Their Cytotoxic Activities Against Lung and Colon Cancer Cells in Vitro and in Silico. [PDF]

J Appl Toxicol
ABSTRACT Three new Zn (II), Cu (II) and Mn (II) complexes have been synthesized from 5‐hydroxy‐1,4‐naphthoquinone (HNQ). Elemental analysis, magnetic susceptibility, UV–Vis, IR and Mass spectrometry have all been used to explore the structural characterization of these compounds.
Öztatlıcı M, Birimoğlu T, Güler S, Çolaksel RB, Husunet MT, Sönmez M.   +5 more
europepmc   +2 more sources

Antibacterial Effect and Mechanism of Juglone from Walnut Green Husk against Escherichia coli [PDF]

Shipin Kexue, 2023
The antibacterial activity and mechanism of juglone from walnut green husk against Escherichia coli were studied. E. coli was treated with juglone from walnut green husk in different concentrations.
LU Zhenkang, WU Qingzhi, ZHANG Jian, MAO Xiaoying
doaj   +1 more source

Interactive 360° video to “Polyphenolic extracts of walnut (Juglans regia) green husk containing juglone inhibit the growth of HL-60 cells and induce apoptosis”

Electronic Journal of Biotechnology, 2022
Background: Juglone is a naphthoquinone currently obtained by chemical synthesis with biological activities including antitumor activity. Additionally, juglone is present in the green husk of walnut, which suggests evaluating the effect of GH extracts on
Carmen Soto-Maldonado, Mauricio Vergara-Castro, John Jara-Quezada, Eduardo Caballero-Valdés, Andrea Müller-Pavez, María Elvira Zúñiga-Hansen, Claudia Altamirano   +6 more
doaj   +1 more source

Juglone Attenuates CCl₄-Induced Hepatic Injury in Mice With Associated Modulation of Oxidative Stress and Inflammasome-Related mRNA Expression. [PDF]

Biomed Res Int
Carbon tetrachloride–induced liver injury is a well‐established model of toxic hepatitis, characterized by marked oxidative and inflammatory damage. It remains a relevant experimental system because broadly effective therapeutic options are still limited.
Sohail A, Sufyan R, Asim M, Khan M, Altaf A, Haq MEU, Arshad M, Khalil AAK, Ullah I.   +8 more
europepmc   +2 more sources