Results 141 to 150 of about 17,437 (283)

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo   +7 more
wiley   +1 more source

Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5‐fold increase in the AUC of the CYP2A6 substrates nicotine and letrozole.
Aiden‐Hung P. Nguyen   +8 more
wiley   +1 more source

Evaluation of 3 Compression Forces Using Pressed Juiced Percentage (PJP) and the Relationship to Consumer Juiciness Ratings

open access: gold, 2017
M. M. Kline   +7 more
openalex   +1 more source

Powerful yet challenging: mechanistic niche models for predicting invasive species potential distribution under climate change

open access: yesEcography, EarlyView.
Risk assessments of invasive species present one of the most challenging applications of species distribution models (SDMs) due to the fundamental issues of distributional disequilibrium, niche changes, and truncation. Invasive species often occupy only a fraction of their potential environmental and geographic ranges, as their spatiotemporal dynamics ...
Erola Fenollosa   +4 more
wiley   +1 more source

DETERMINANTS OF UNSAFE HAMBURGER COOKING BEHAVIOR [PDF]

open access: yes
We used a national hamburger preparation survey to estimate a simultaneous equation model of food safety knowledge, attitudes, and hamburger cooking behavior. The results suggest that food safety risk perceptions, palatability attributes, and food safety
Adu-Nyako, Kofi   +3 more
core   +1 more source

Physiology–microhabitat matching may help organisms cope with the thermal and hydric challenges under climate change: a tale of two lizards

open access: yesEcography, EarlyView.
Climate change is significantly affecting biodiversity, and organisms that depend on external temperature – such as ectotherms – are particularly vulnerable to these effects. Microhabitats provide refuge for species, thereby reducing exposure to thermal and hydric stress under climate change.
Carolina Reyes‐ Puig   +3 more
wiley   +1 more source

Tenderness and Juiciness of Beef Steaks from Varying Hot Carcass Weights

open access: gold, 2019
M. Fevold   +4 more
openalex   +1 more source

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