Model‐Informed Evaluation of Hydroxyurea Exposure During Lactation
Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Anhar Hosawi +5 more
wiley +1 more source
<i>NTRK</i> Gene Fusions: A Compendium of Fusion Partners and Tumor Types. [PDF]
Yang SR +14 more
europepmc +1 more source
Harmonizing Social Impact Assessment in the Bioeconomy: A Cross‐Regional Fuzzy‐Delphi Approach
ABSTRACT The bioeconomy transition risks underrepresenting social sustainability, while existing Social Life Cycle Assessment (S‐LCA) applications remain insufficient for comparison and decision support due to heterogeneous and non‐standardized selection of social impact categories. This study proposes a cross‐regional baseline set of impact categories
Julia Lessa Feitosa Virgolino +2 more
wiley +1 more source
UNICORN: a deep learning model for integrating multi-stain data in histopathology. [PDF]
Koch V +8 more
europepmc +1 more source
On the Design of a Class of Analog Filters Whose Impulse Response Is a Mittag‐Leffler Function
Fractional‐order filters whose impulse response is a Mittag‐Leffler (M‐L) function in any of its known forms are summarized in this work. Simulation results using Cadence and experimental results using an FPAA validate the introduced concept. ABSTRACT Fractional‐order filters whose impulse response is a Mittag‐Leffler (M‐L) function in any of its known
Julia Nako +3 more
wiley +1 more source
Interpretable Machine Learning to Understand Wildfire Toxicity: Bridging Chemicals, Omics, and Toxicological Outcomes via Symbolic Regression with Novel Feature Scoring. [PDF]
Chappel JR +6 more
europepmc +1 more source
Internationalising the teacher education curriculum: An analysis of syllabi and student experiences
Abstract Internationalisation has increasingly become a key dimension of quality in initial teacher education (ITE) programmes. Although it is recognised as a means to strengthen future teachers' competencies and expand their professional knowledge, it remains underdeveloped in practice.
Nafsika Alexiadou, Mai Trang Vu
wiley +1 more source
Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios as Predictors of Complicated Acute Appendicitis: A Retrospective Cohort Study. [PDF]
Nicastro RG +9 more
europepmc +1 more source
ABSTRACT Background Anal cancer rates are rising among women, immunocompromised individuals, and Men who have sex with Men (MSM), independent of HIV status. While high‐resolution anoscopy remains the diagnostic standard, limited access has increased interest in alternative screening.
Daisy Maharjan +5 more
wiley +1 more source

