Results 221 to 230 of about 29,416 (289)

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source

Bacillus mycoides bacteremia after dog bite trauma in a patient on chronic suppressive antibiotics. [PDF]

IDCases
Diggins C, Tedeschi C, Jandro J, Hysell K.   +3 more
europepmc   +1 more source

Distinct Ligand‐ and Metal‐Centered Phosphorescence in a Terbium Carbazolyl Complex

Chemistry – A European Journal, EarlyView.
Terbium and lanthanum carbazolide complexes show two distinct modes of luminescence: Strongly temperature‐dependent narrow‐line terbium emission could be induced. In addition, both the terbium and the lanthanum complexes show broad‐line interligand emission processes with excited states of microsecond life‐time.
Xiaofei Sun, Frederic Krätschmer, Julia Feye, Marcel Lukanowski, Dominik Graf, Sergei Lebedkin, Manfred Kappes, Florian Weigend, Peter W. Roesky, Alexander Hinz   +9 more
wiley   +1 more source

Ab-SELDON: Leveraging Diversity Data for an Efficient Automated Computational Pipeline for Antibody Design. [PDF]

J Chem Inf Model
Sampaio JV, Costa AHS, Albuquerque AO, Souza JS, Almeida DS, Gaieta EM, Almeida MV, Sartori GR, Silva JHM.   +8 more
europepmc   +1 more source

Geometry‐Based Neural‐Network Prediction of Electron Localization Function Topology in Dense Hydrogen

Chemistry – A European Journal, EarlyView.
We present a machine‐learning framework that predicts the electron localization function (ELF) of dense hydrogen directly from atomic geometry, bypassing explicit electronic‐structure calculations. Trained on ab initio data for fluid hydrogen across multiple pressures, the model achieves high accuracy and reveals pressure‐dependent nonlocal ...
Xiaoyu Wang, Miriam Marqués, Sergio Gómez, Francesc Serratosa, Eva Zurek, Julia Contreras‐García   +5 more
wiley   +1 more source

Improving Population Pharmacokinetic Modelling with Artificial Patients using Generative Artificial Intelligence. [PDF]

Pharmacol Res Perspect
Schöning V, Hammann F.
europepmc   +1 more source

Synthesis of the Phospha‐Wittig Reagent Me3P = P(C2F5) and Generation of a Phospanyl‐Wittig Derivative Me3P = C(CF3)P(C2F5)F

Chemistry – A European Journal, EarlyView.
The first example of a simple alkylated phosphinidene‐adduct (“phospha‐Wittig”) is reported. The synthesis of Me3PPC2F5 was enabled through reaction of the cyclotetraphosphane (PC2F5)4 with PMe3. The phosphanyl‐functionalized Wittig reagent Me3PC(CF3)P(C2F5)F was prepared by treating the diphosphane P2(C2F5)4 with PMe3.
Lukas Hartmann, Hannah Koch, Julia Bader, Beate Neumann, Jan‐Hendrik Lamm, Hans‐Georg Stammler, Mira Kessler, Berthold Hoge   +7 more
wiley   +1 more source

Genomic estimates of Identity-By-Descent relationships in large scale data sets. [PDF]

Genet Sel Evol
Meuwisen T, Yu X, Berg P.
europepmc   +1 more source

Germylium Catalyzed Dehydrofluorination Reactions of Fluorinated Alkanes

Chemistry – A European Journal, EarlyView.
Dehydrofluorination reactions of fluorinated alkanes catalyzed by germylium ions are reported. Computational studies of the mechanism revealed an E2 type mechanism involving a germane as a base to facilitate olefin formation in competition with an SN2 mechanism for hydrodefluorination.
Julie Borel, Morten Lehmann, Martin Kaupp, Thomas Braun   +3 more
wiley   +1 more source

Urine-Derived iPSC Neurospheres Uncover Proteomic Correlates of Clinical Severity in Dravet Syndrome. [PDF]

J Neurochem
Martins M, Nugue G, Aguiar A, Souza LRQ, Abrantes PV, Trajano JR, Stelling M, Junqueira M, Rehen S, Guimarães MZP.   +9 more
europepmc   +1 more source