Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Forward Starting Option Pricing under Double Fractional Stochastic Volatilities and Jumps
Fractal and FractionalThis paper aims to provide an effective method for pricing forward starting options under the double fractional stochastic volatilities mixed-exponential jump-diffusion model.
Sumei Zhang, Haiyang Xiao, Hongquan Yong
doaj +1 more source
Relación entre la fuerza máxima en squat y acciones de salto, sprint y golpeo de balón. (Relationship among maximal strength in squat exercise, jump, sprint and kicking ball performance.) [PDF]
Revista Internacional de Ciencias del Deporte, 2008 ResumenEl objetivo del presente estudio fue analizar las posibles relaciones entre la fuerza máxima en squat y accionesexplosivas de salto, sprint y golpeo de balón.
Alfredo Arija Blázquez +4 more
doaj
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Factors contributing to jump heights in two-foot running jumps with and without a basketball
Frontiers in Sports and Active LivingIntroductionTwo-foot running jumps (TFRJs) are used by basketball players during games and evaluations for maximum jump height with or without a ball.
Jun Ming Liu, Antonia Zaferiou
doaj +1 more source
Short-Term Effects of Suspension Training on Strength and Power Performances
Journal of Functional Morphology and Kinesiology, 2018 Suspension Training (ST) workouts include a variety of movements requiring the individual to maintain balance while performing various resistance exercises in an interval fashion.
Giuseppe Francesco Giancotti +3 more
doaj +1 more source
One small leap for the jumping spider but a giant step for vision science [PDF]
, 2009 Robert R. Jackson, Duane P. Harland
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Functional Movement Screen Scores and Physical Performance among Youth Elite Soccer Players
Sports, 2017 This study had two main objectives: (1) to determine if differences in Functional Movement Screen (FMS) scores exist between two levels of competition; and (2) to analyze the association between FMS individual and overall scores and physical performance ...
Bruno Silva +3 more
doaj +1 more source
Testing for Jump Spillovers Without Testing for Jumps
Journal of the American Statistical Association, 2019 This article develops statistical tools for testing conditional independence among the jump components of the daily quadratic variation, which we estimate using intraday data. To avoid sequential bias distortion, we do not pretest for the presence of jumps.
Corradi, Valentina +2 more
openaire +5 more sources