Results 151 to 160 of about 1,337,805 (372)
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
RAPID PREPARATION OF FROZEN SECTIONS FOR COMPARATIVE HISTOCHEMICAL STUDIES: JUMP-MOUNTING OF PAIRED FROZEN SECTIONS ON SEMI-HEATED MICROSLIDES [PDF]
, 1961 IAN I. IRONS
openalex +1 more source
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source
Jump resonance in a third order nonlinear control system [PDF]
, 1961 Wellington W. Koepsel
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Open Access Journal of Sports Medicine, 2018 Terje Dalen,1 Ørjan Øverås,1 Roland van den Tillaar,1 Boye Welde,2 Erna Dianne von Heimburg1 1Department of Physical Education and Sport Science, Nord University, Levanger, Norway; 2UiT The Arctic University of Norway, School of Sport
Dalen T +4 more
doaj
Closure to “General Solution of the Hydraulic Jump in Sloping Channels” [PDF]
, 1963 Praxitelis A. Argyropoulos
openalex +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Data‐driven performance metrics for neural network learning
International Journal of Adaptive Control and Signal Processing, EarlyView., 2023 Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri +2 more
wiley +1 more source
Journal of Functional Morphology and KinesiologyVolleyball primarily focuses on technical and tactical training with a ball. However, there is growing interest in integrating fitness training into volleyball practice, particularly to enhance explosive strength through plyometric methods, but there is ...
Giovanni Esposito +4 more
doaj +1 more source