Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Limit Theorems for Reinforced Jump Processes on Regular Trees [PDF]
Consider a vertex-reinforced jump process defined on a regular tree, where each vertex has exactly b children, with b >= 3. We prove the strong law of large numbers and the central limit theorem for the distance of the process from the root.
Andrea Collevecchio
core
The ⋆-vertex-reinforced jump process
The Annals of ProbabilityWe investigate the nonreversible generalization of the Vertex-Reinforced Jump Process (VRJP), called the ⋆-Vertex-Reinforced Jump Process (⋆-VRJP) and introduced in Bacallado, Sabot, Tarrès (2020). It can be seen as the continuous-time counterpart to the ⋆-Edge-Reinforced Random Walk (⋆-ERRW) (see Bacallado, Chodera, Pande (2009); Bacallado, Sabot ...
Sabot, Christophe, Tarrès, Pierre
openaire +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Exchange Options Under Jump-Diffusion Dynamics [PDF]
Margrabe provides a pricing formula for an exchange option where the distributions of both stock prices are log-normal with correlated Wiener components.
Carl Chiarella, Gerald H. L. Cheang
core
Improved Dynamic Event-Triggered Robust Control for Flexible Robotic Arm Systems with Semi-Markov Jump Process. [PDF]
Sensors (Basel), 2023 Zhang H, Chen Z, Ao W, Shi P.
europepmc +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Approximation of Jump Diffusions in Finance and Economics [PDF]
In finance and economics the key dynamics are often specified via stochastic differential equations (SDEs) of jump-diffusion type. The class of jump-diffusion SDEs that admits explicit solutions is rather limited.
Nicola Bruti-Liberati, Eckhard Platen
core
Using the Lambert function in an exchange process with a time delay
Electronic Journal of Qualitative Theory of Differential Equations, 2012 The current work describes the application of delay differential equations to the physical process of spin exchange, which affects the lineshape in pulsed nuclear magnetic resonance (NMR).
D. Gamliel
doaj +1 more source
A Markov jump process approach to modeling blood donor status: Donor retention and attrition rates at a blood service center in Zimbabwe. [PDF]
Health Sci Rep, 2022 Chikobvu D, Chideme C.
europepmc +1 more source