Results 141 to 150 of about 62,486 (251)
Molecular Oncology, Volume 20, Issue 11, Page 2936-2954, November 2026.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Frontiers in ImmunologyIntroductionFollowing the approval of Chimeric Antigen Receptor T-cell Immunotherapy(CAR-T) in multiple countries, the Food and Drug Administration (FDA) approved tumor-infiltrating lymphocytes (TILs) and T-cell receptor-engineered T cells (TCR-T ...
Zhaoyi Wang +10 more
doaj +1 more source
Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy
Advanced Science, Volume 13, Issue 61, 3 November 2026.By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng +16 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2012 目的通过体外细胞实验研究氯化甲基汞（Methyl mercury chloride,MMC）和甲氨蝶呤（Methotrexate,MTX）对人T淋巴细胞白血病细胞（Jurkat）凋亡的影响。方法 Jurkat细胞经1.25、2.5、5、10、20μmol.L-1 MMC和MTX作用24h。应用四甲基偶氮唑盐（MTT）比色法检测不同浓度MMC和MTX对Jurktat细胞增殖的抑制作用;采用流式细胞术应用AnnexinⅤ-FITC/PI双染法检测不同浓度MMC和MTX对Jurktat细胞凋亡的影响。结果 ...
赵玲玲 +5 more
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Abrin mediated protein synthesis inhibition and apoptosis in Jurkat cells.
, 2014 (A) Jurkat cells were treated with different concentrations of abrin for 8 h and protein synthesis was measured by incorporation of [3H]-leucine. (B) Jurkat cells were treated with varying concentrations (16 nM – 0.016 nM) of abrin for 12 h.
Ritu Mishra (541530) +1 more
core +1 more source
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, Volume 13, Issue 61, 3 November 2026.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source
PTxM-mediated aggregation of Jurkat cells.
, 2013 A. Analysis of by flow cytometry showing the forward scatter and side scatter profiles. Control, untreated cells (1 hr at 37°C); PTxM treated (7.9 nM for 1 hr at 37°C). B.
John J. Monaco (453185) +4 more
core +1 more source
Arthritis &Rheumatology, Volume 78, Issue 11, Page 2365-2377, November 2026.Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki +8 more
wiley +1 more source
Drug Design, Development and Therapy, 2016 Tingfang Yang,1 Shuluan Yao,2 Xianfeng Zhang,3 Yan Guo2 1Department of Pediatrics, Jining No 1 People’s Hospital, Shandong Province, People’s Republic of China; 2Department of Respiratory Medicine, Jining Medical University Affiliated ...
Yang T, Yao S, Zhang X, Guo Y
doaj
Iranian Biomedical Journal, 2020 Background: Recently, modification of T cells with chimeric antigen receptor (CAR) has been an attractive approach for adoptive immunotherapy of cancers. Typically, CARs contain a single-chain variable domain fragment (scFv).
Mahmoud Hassani +8 more
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