Results 71 to 80 of about 719,976 (345)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Model describes sustainable long-term recycling of saline agricultural drainage water

open access: yesCalifornia Agriculture, 2003
Due to high water tables, the western San Joaquin Valley is prone to high salinity in drainage water, which requires appropriate management and disposal in order to sustain agricultural productivity.
David E Birkle, William A Jury, Iddo Kan
doaj   +1 more source

Student Film Festival 2017 Playbill [PDF]

open access: yes, 2017
Student Film Festival 2017 Providence College Department of Theatre, Dance & Film Angell Blackfriars Theatre May 4, 2017, 7:00PM Films by Providence College Students Introductory Remarks – Rev. Kenneth Gumbert, O.P.
Providence College
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

12 Confused Men: Using Flowchart Verdict Sheets To Mitigate Inconsistent Civil Verdicts [PDF]

open access: yes, 2014
The finality of jury verdicts reflects an implicit societal acceptance of the soundness of the jury\u27s decision. Regardless, jurors are not infallible, and the questions they are often tasked with deciding are unfortunately neither obvious nor clear ...
Fang, Jerry J.
core   +1 more source

Stability borders of feedback control of delayed measured systems

open access: yes, 2004
When stabilization of unstable periodic orbits or fixed points by the method given by Ott, Grebogi and Yorke (OGY) has to be based on a measurement delayed by $\tau$ orbit lengths, the performance of unmodified OGY method is expected to decline.
A. W. Hübler   +4 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

VI Tournament of Architectural Graphics “Line of Thought” 2024

open access: yesПроект Байкал
On 23 May 2024, the VI Tournament of Architectural Graphics “Line of Thought”, established by the Iakov Chernikhov International Foundation in 2018, was held within the framework of the XXIX International Exhibition of Architecture and Design ARCH ...
Людмила Сысоева
doaj   +1 more source

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