Results 61 to 70 of about 632,340 (320)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

EnsembleFam: towards more accurate protein family prediction in the twilight zone

BMC Bioinformatics, 2022
Background Current protein family modeling methods like profile Hidden Markov Model (pHMM), k-mer based methods, and deep learning-based methods do not provide very accurate protein function prediction for proteins in the twilight zone, due to low ...
Mohammad Neamul Kabir, Limsoon Wong
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Robustness- and complexity-oriented characterization of supply networks’ structures [PDF]

, 2016
In the past period the efficiency aspects of production were emphasized, sometimes even overemphasized. As a result, the vulnerability of production structures was put in the background, and consequently, by now, it is usually beyond its acceptable ...
Cheng, Duan, ElMaraghy, Kito, Modrak, Monostori, Schneider, Serdarasan, Stricker, Tolio, Vlajic, Wiendahl, Zhou   +12 more
core   +1 more source

Some New Results For Soft b-Metric Space

Wasit Journal for Pure Sciences
The objective of this search, is to introduce some important new results for generalized type of b-metric space which is soft b-metric space up on non-empty soft set.
Lina Aydeen Hussein
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

WOODY: A Post-Process Method for Smartphone-Based Activity Recognition

IEEE Access, 2018
In the past decade, the rapid popularization of smartphone has provided a promising direction for human activity recognition. Despite identifying a variety of movements without any complicated wearable device, the smartphone-based activity recognition is
Changhai Wang, Yuwei Xu, Hui Liang, Wanwei Huang, Ling Zhang   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

COMPARATIVE STUDY OF DIFFERENT FORMS OF MATERIAL PROCUREMENT WITH RESPECT TO THE LOGISTIC AND PURCHASING ACTIVITIES OF THE MANUFACTURING COMPANY

Perner’s Contacts, 2011
The contribution brings an insight into the different forms of material procurement. It compares so-called traditional approach of procurement with Just-in-Time and Just-in-Sequence approaches and points out main characteristics of each system with ...
Marián Sedliak, Marián Šulgan
doaj  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source