Results 91 to 100 of about 2,077,123 (300)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

ASSESSING MORAL TRAGEDY PACIFISM* [PDF]

open access: yesKriterion
Pacifism and just war theory share the same binary approach to analyze the morality of war. According to binarism, any war is either morally justified or morally unjustified and when waging a war is morally unjustified, not waging that war is morally ...
Federico German Abal
doaj   +1 more source

The Ethics Of Unwinnable War [PDF]

open access: yes, 2017
According to just war theory, military campaigns should only be fought as a last resort, with the goal of correcting a grave evil, and where there is a high probability of success. But what happens when a military campaign unravels and becomes unwinnable?
Tierney, Dominic
core   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Someter Al Enemigo Sin Librar Combate

open access: yesRevista de Estudios Sociales, 2003
This article intends to investigate the meaning of war in a Chinese text wrote more than 300 years ago: The Art of War, by Sun Tzu. The essay uses Mao Tse Tung difference between "just wars" and "unjust wars", to ask about the origin of the "just war ...
Jaime Barrera Parra
doaj  

Beyond the Battlefield: The Park That Once Was Stevens’s Furnace

open access: yes, 2016
If you’re a frequent reader of the Compiler, it comes as no news to you that the Gettysburg area is historic for more than just its battlefield. From a pre-war African American community to the World War I tank camp commanded by a young Dwight Eisenhower,
Lavery, Kevin P.
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Putting the War Back in Just War Theory: A Critique of Examples [PDF]

open access: yes, 2017
Analytic just war theorists often attempt to construct ideal theories of military justice on the basis of intuitions about imaginary and sometimes outlandish examples, often taken from non-military contexts. This article argues for a sharp curtailment of
Mark, Rigstad
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

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