Results 101 to 110 of about 6,397,857 (332)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Supreme Threat: The Just War Tradition and the Invasion of Iraq
, 2006 This work intends to be an application and understanding of the Christian just war tradition as it pertains to the actions of the United States government in Iraq.
Fallaize, James
core +1 more source
War Is the Storm—Clausewitz, Chaos, and Complex War Studies [PDF]
, 2022 Complexity theories indeed do apply to war, and Clausewitz’s theories were the first to grapple with them. War is nonlinear, but the parallels between war and complexity science, and between complexity science and Clausewitz, do not stop with ...
Friedman, B. A.
core
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Just Cause and the Continuous Application of Jus Ad Bellum
, 2018 What one is ultimately interested in with regard to “just cause” is whether a specific war, actual or potential, is justified – for example, the concrete historical 2003 Iraqi war against the invading Coalition forces, or a war one is contemplating in ...
Steinhoff, UB
core +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Serviciul militar și Războiul Drept – o abordare diacronică
TheoRhēma, 2013 The current paper deals with the intellectual history and the history of Christian practice with regard to military service and Just War. The justification for this study from an historical point of view has become obvious on account of the fact that it
Zoltán Szallós-Farkas
doaj +2 more sources
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source