Results 121 to 130 of about 6,397,857 (332)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Just war theory and scapegoat mechanism: An analysis of missio Dei and social order
HTS Teologiese Studies/Theological StudiesThis article examined Augustine’s just war theory through René Girard’s scapegoat mechanism, as posited in his theory of mimetic desire. Augustine, in his development of just war theory, adopted a realist approach to justify the ethical criteria for ...
Godfrey T. Baleng
doaj +1 more source
Map of Persia & Afghanistan [cartographic material].
, 1906 Map of Persia and Afghanistan showing international boundaries, transportation, communication, water features and populated places. Relief shown by hypsometric tints and spot heights.; "Topographic Section, General staff No.
Great Britain. War Office.
core
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
New Caledonia [cartographic material].
, 1942 1st ed. Relief shown by hachures and spot heights.; Map of New Caledonia showing railways, tramways, roads, mule tracks, footpaths, trigonometrical points, forests and marshes.; Includes inset "Environs de Noumea".; "Copied from a French map dated 1903 ...
Great Britain. War Office.
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
, 1942 1st ed. Maps of French Islands of the Indian Ocean showing arrondissement boundaries, roads, tracks, railways, glaciers or ice caps, lava, canals and water features.
Great Britain. War Office.
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source