Results 121 to 130 of about 2,077,123 (300)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The ethics of diplomatic criticism: The Responsibility to Protect, Just War Theory and Presumptive Last Resort. [PDF]
Eur J Int Relat, 2015 Pattison J.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Kořeny teorie spravedlivé války: od Platóna ke Grotiovi
Theatrum Historiae, 2008 The so-called “just war theory” is one of the few instances in the history of human endeavors when organized violence (i.e. war) directly meets philosophy.
Jiří Hutečka
doaj
Levi Pennington Writing to Don Beede, February 28, 1947
, 1947 Levi Pennington writing to Don Beede, who was just released by the court, telling him about the new resolutions of the Oregon Council of Churches against war, drinking, gambling, and calling for more relief.
Pennington, Levi T.
core
Barack Obama as Just War Theorist: The Libyan Intervention [PDF]
, 2012 President Barack Obama has clearly placed himself in the just war tradition, and so we may ask how successful has President Obama in fact been as just war theorist?
van der Linden, Harry
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
The official student newspaper of the University of Alaska Southeast - Juneau [PDF]
, 1990 MIXED REVIEWS ON ASSESSMENT -- USUAS GETS POLITICAL -- Maggie for President -- Indifference towards war alarms student -- Swedish student seeks correspondence with Alaskan pen pal -- Take out the politics -- Counselor Follett bade farewell -- Nunsense ...
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