Results 51 to 60 of about 2,882,932 (292)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Status of the Criminal Justice Information Sharing System; Legislative report

, 2011
Annual; Began with Jan. 1, 2009.; Mandated by Public Act 08-01, section 40 (h), an Act Concerning Criminal Justice Reform.; Imprint from letter of transmittal.; Harvested from the web on 7/27 ...
Connecticut. Criminal Justice Information System Governing Board.
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Unpacking social scoring systems and their impact on fairness and digital dignity

Big Data & Society
Governments worldwide are increasingly deploying algorithmic systems that influence citizens’ rights, benefits, and opportunities. These systems often resemble social scoring systems (SSSs) in functionality and societal impact.
Maud Reveilhac, Vlada Druta, Aurelia Tamò-Larrieux, Marlène Sapin   +3 more
doaj   +1 more source

Una justícia pròxima i eficaç des de les comunitats autònomes: La introducció del ‘Rechtspfleger’ alemany [PDF]

Revista d'Estudis Autonòmics i Federals, 2012
This paper explores the possibility for the provisions of the Government ofCatalonia to contribute to a closer and more effective practice of justice,despite the limitations of competence derived from the constitutional andstatutory frameworks. The paper
Antonio Cereijo
doaj  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Good governance e o Conselho Nacional de Justiça

Revista Direito GV
Os sistemas judiciais, no Brasil e em todo o mundo, estão passando por grandes modificações nas últimas décadas. No Brasil, de modo especial após a constituição federal de 1988, verifica-se um importante aumento da judicialização das relações sociais, da
Antonio César Bochenek, Vinicius Dalazoana, Vinicius Rafael Rissetti   +2 more
doaj   +1 more source

An Exploratory Study of Police Officers: Low Compassion Satisfaction and Compassion Fatigue

Frontiers in Psychology, 2019
Background: Compassion fatigue, or the physical, mental, and emotional state experienced by professionals that assist others in distress, has been well documented in several caring professions such as nurses, firefighters, and emergency medical ...
Heath Blair Grant, Cathryn F. Lavery, John Decarlo   +2 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source