Results 1 to 10 of about 1,782 (159)

Three-year outcomes of gonioscopy-assisted transluminal trabeculotomy for juvenile-onset primary open-angle glaucoma: a retrospective study [PDF]

BMC Ophthalmology
Objectives This retrospective study evaluates the three-year efficacy and safety of gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with juvenile-onset primary open-angle glaucoma (JOAG).
Baiyu Hu, Suju Liu, Hanying Fan, Liuzhi Zeng   +3 more
doaj   +5 more sources

Outcomes of gonioscopy-assisted transluminal trabeculotomy in juvenile-onset primary open-angle glaucoma. [PDF]

Eye (Lond), 2021
To report the outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) for juvenile-onset primary open-angle glaucoma (JOAG).A consecutive case series of JOAG patients who underwent GATT was reviewed with follow-up period of up to 18 months. Intraocular pressure (IOP), number of glaucoma medications and success rate were compared between eyes ...
Wang Y, Wang H, Han Y, Shi Y, Xin C, Yin P, Li M, Cao K, Wang N.   +8 more
europepmc   +5 more sources

Coinheritance of OLFM2 and SIX6 variants in a Chinese family with juvenile-onset primary open-angle glaucoma: A case report. [PDF]

World J Clin Cases, 2021
Juvenile-onset primary open-angle glaucoma (JOAG), characterized by severe elevation of intraocular pressure and optic neuropathy prior to the age of 40, is a rare subtype of primary open-angle glaucoma. Several genetic mutations have been associated with JOAG.The proband patient was a young male, diagnosed with primary open-angle glaucoma at the age ...
Yang X, Sun NN, Zhao ZN, He SX, Zhang M, Zhang DD, Yu XW, Zhang JM, Fan ZG.   +8 more
europepmc   +5 more sources

Genetic screening in a large family with juvenile onset primary open angle glaucoma [PDF]

British Journal of Ophthalmology, 2000
A number of genetic loci have been implicated in the pathogenesis of primary open angle glaucoma (POAG). The aim of this study was to identify the genetic cause of POAG in a large Scottish family and, if possible, offer genetic screening and advice to family members.Family members were examined to determine their disease status.
Adam Booth
openalex   +4 more sources

Novel TIGR/MYOC mutations in families with juvenile onset primary open angle glaucoma. [PDF]

Journal of Medical Genetics, 1998
Mutations in the trabecular meshwork induced glucocorticoid response protein (TIGR) or myocilin (MYOC) has recently been shown to cause juvenile onset primary open angle glaucoma (JOAG). In this study, we identified two new mutations (Asp380Ala and Ser502Pro) in two British families and another (Pro370Leu) in a French-Canadian family.
Diliana Stoilova, Anne H. Child, Glen Brice, Trushna Desai, Magda Barsoum‐Homsy, Nihal Özdemir, Line Chevrette, M F Adam, H J Garchon, Ronald P. Crick, M. Sarfarazi   +10 more
openalex   +4 more sources

A novel Asp380Ala mutation in the GLC1A/myocilin gene in a family with juvenile onset primary open angle glaucoma. [PDF]

Journal of Medical Genetics, 1998
Glaucoma describes a clinically and genetically heterogeneous group of diseases that result in optic neuropathy and progressive loss of visual fields. A gene for juvenile onset primary open angle glaucoma JOAG) has recently been mapped to 1q21-31. Mutations in the trabecular meshwork induced glucocorticoid response gene (TIGR, also known as myocilin or
Avril Kennan, Fiona C. Mansergh, John H. Fingert, Tyson A. Clark, Carmen Ayuso, Paul F. Kenna, Peter Humphries, G. Jane Farrar   +7 more
openalex   +4 more sources

Juvenile onset primary open angle glaucoma in members of a single Indian family-A case series

IOSR Journal of Dental and Medical Sciences, 2014
We report a rare case series of bilateral juvenile open-angle glaucoma (JOAG), in three young girls of a same family with discussion of current understanding of its pathogenesis, differential diagnosis, and management. Two sisters named A and B aged 9yrs and 16yrs respectively presented in eye opd chiefly for blurring of vision and were found to have ...
Iosr Journals, Dr.Ibohal Salam Dr.TaranpreetKaur   +1 more
  +4 more sources

Screening of CYP1B1 Arg368His as predominant mutation in North Indian primary open angle glaucoma and juvenile onset glaucoma patients.

Molecular biology research communications, 2018
In India, mutations in Cytochrome P450 (CYP1B1) are a predominant cause of not only primary congenital glaucoma (PCG) but also involved in primary open angle glaucoma (POAG) and juvenile onset glaucoma (JOAG). After ethical clearance, 100 POAG patients, 30 primary angle closure glaucoma (PACG) patients and 130 ethnically matched controls were recruited
Avneet Kaur, Vanita Vanita, Jairup Singh
openalex   +4 more sources

A Genome-wide Scan Maps a Novel Juvenile-Onset Primary Open-Angle Glaucoma Locus to 15q

Investigative Opthalmology & Visual Science, 2006
To map the disease-associated locus of a family with autosomal dominant juvenile-onset primary open-angle glaucoma (JOAG).A complete ophthalmic examination was conducted, and genomic DNA was obtained from 25 members of a Chinese family, of which eight were confirmed as having JOAG.
Dan Yi Wang, Baojian Fan, John K.H. Chua, Pancy O. S. Tam, Christopher Kai-Shun Leung, Dennis S.C. Lam, Chi Pui Pang   +6 more
openalex   +3 more sources

A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q.

Molecular vision, 2006
To map the disease-associated locus of a family with autosomal dominant juvenile-onset primary open angle glaucoma (JOAG) and to screen the novel glaucoma gene WD repeat domain 36 (WDR36).Complete ophthalmic examination and genomic DNA were obtained from 27 family members, in which nine were confirmed JOAG patients.
Chi Pui Pang, Baojian Fan, Oscar Canlas, Dan Yi Wang, Stéphane Dubois, Pancy Oi Sin Tam, Dennis S.C. Lam, Vincent Raymond, Robert Ritch   +8 more
openalex   +2 more sources