Results 1 to 10 of about 3,945 (185)

Three-year outcomes of gonioscopy-assisted transluminal trabeculotomy for juvenile-onset primary open-angle glaucoma: a retrospective study [PDF]

BMC Ophthalmology
Objectives This retrospective study evaluates the three-year efficacy and safety of gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with juvenile-onset primary open-angle glaucoma (JOAG).
Baiyu Hu, Suju Liu, Hanying Fan, Liuzhi Zeng   +3 more
doaj   +4 more sources

Outcomes of gonioscopy-assisted transluminal trabeculotomy in juvenile-onset primary open-angle glaucoma. [PDF]

Eye (Lond), 2021
To report the outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) for juvenile-onset primary open-angle glaucoma (JOAG).A consecutive case series of JOAG patients who underwent GATT was reviewed with follow-up period of up to 18 months. Intraocular pressure (IOP), number of glaucoma medications and success rate were compared between eyes ...
Wang Y, Wang H, Han Y, Shi Y, Xin C, Yin P, Li M, Cao K, Wang N.   +8 more
europepmc   +3 more sources

Coinheritance of OLFM2 and SIX6 variants in a Chinese family with juvenile-onset primary open-angle glaucoma: A case report. [PDF]

World J Clin Cases, 2021
Juvenile-onset primary open-angle glaucoma (JOAG), characterized by severe elevation of intraocular pressure and optic neuropathy prior to the age of 40, is a rare subtype of primary open-angle glaucoma. Several genetic mutations have been associated with JOAG.The proband patient was a young male, diagnosed with primary open-angle glaucoma at the age ...
Yang X, Sun NN, Zhao ZN, He SX, Zhang M, Zhang DD, Yu XW, Zhang JM, Fan ZG.   +8 more
europepmc   +3 more sources

Genes of the unfolded protein response pathway harbor risk alleles for primary open angle glaucoma. [PDF]

PLoS ONE, 2011
The statistical power of genome-wide association (GWA) studies to detect risk alleles for human diseases is limited by the unfavorable ratio of SNPs to study subjects.
Mary Anna Carbone, Yuhong Chen, Guy A Hughes, Robert N Weinreb, Norman A Zabriskie, Kang Zhang, Robert R H Anholt   +6 more
doaj   +1 more source

Exome sequencing identifies procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 mutations in primary congenital and juvenile glaucoma

Indian Journal of Ophthalmology, 2021
Purpose: To report the association of procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (PLOD2) mutations with bilateral primary congenital glaucoma (PCG) in monozygotic twins and with nondominant juvenile-onset primary open-angle glaucoma (JOAG ...
Viney Gupta, Bindu I Somarajan, Gagandeep Kaur, Shikha Gupta, Renu Singh, Dibyabhaba Pradhan, Harpreet Singh, Punit Kaur, Anshul Sharma, Bindia Chawla, Anisha Pahuja, Rajesh Ramachandran, Arundhati Sharma   +12 more
doaj   +1 more source

Gonioscopy-assisted transluminal trabeculotomy for open-angle glaucoma with failed incisional glaucoma surgery: two-year results

BMC Ophthalmology, 2023
Background To evaluate the safety and efficacy of gonioscopy-assisted transluminal trabeculotomy (GATT) in treating patients with open-angle glaucoma (OAG) who had failed prior incisional glaucoma surgery.
Yiwei Wang, Weijia Zhang, Chen Xin, Jinghong Sang, Yang Sun, Huaizhou Wang   +5 more
doaj   +1 more source

A rare optineurin mutation in an Indian family with coexistence of JOAG and PCG

Indian Journal of Ophthalmology, 2023
Purpose: This study focused on the genetic screening of Myocilin (MYOC), Cytochrome P450 family 1 subfamily B member 1 (CYP1B1), Optineurin (OPTN), and SIX homeobox 6 (SIX6) genes in a family with coexistence of primary congenital glaucoma (PCG) and ...
Manoj Yadav, Anshu Yadav, Aarti Bhardwaj, Chand Singh Dhull, Sumit Sachdeva, Ritu Yadav, Mukesh Tanwar   +6 more
doaj   +1 more source

Genetic screening in a large family with juvenile onset primary open angle glaucoma [PDF]

British Journal of Ophthalmology, 2000
A number of genetic loci have been implicated in the pathogenesis of primary open angle glaucoma (POAG). The aim of this study was to identify the genetic cause of POAG in a large Scottish family and, if possible, offer genetic screening and advice to family members.Family members were examined to determine their disease status.
A P, Booth, R, Anwar, H, Chen, A J, Churchill, J, Jay, J, Polansky, T, Nguyen, A F, Markham   +7 more
openaire   +2 more sources

Functional and Structural Analyses of CYP1B1 Variants Linked to Congenital and Adult-Onset Glaucoma to Investigate the Molecular Basis of These Diseases [PDF]

, 2016
Glaucoma, the leading cause of irreversible blindness, appears in various forms. Mutations in CYP1B1 result in primary congenital glaucoma (PCG) by an autosomal recessive mode of inheritance while it acts as a modifier locus for primary open angle ...
Banerjee, Antara, Chakrabarti, Saikat, Chakraborty, Abhijit, Chakraborty, Subhadip, Ray, Kunal   +4 more
core   +13 more sources

Novel TIGR/MYOC mutations in families with juvenile onset primary open angle glaucoma. [PDF]

Journal of Medical Genetics, 1998
Mutations in the trabecular meshwork induced glucocorticoid response protein (TIGR) or myocilin (MYOC) has recently been shown to cause juvenile onset primary open angle glaucoma (JOAG). In this study, we identified two new mutations (Asp380Ala and Ser502Pro) in two British families and another (Pro370Leu) in a French-Canadian family.
D, Stoilova, A, Child, G, Brice, T, Desai, M, Barsoum-Homsy, N, Ozdemir, L, Chevrette, M F, Adam, H J, Garchon, R, Pitts Crick, M, Sarfarazi   +10 more
openaire   +2 more sources