Results 11 to 20 of about 1,926 (144)

Estimating the age of the p.Cys433Arg variant in the MYOC gene in patients with primary open-angle glaucoma. [PDF]

PLoS ONE, 2018
The aim of this study was to estimate the age of the Cys433Arg (c.1297T>C, p.Cys433Arg) variant by comparing the genotypes of individuals affected and not affected by primary open angle glaucoma juvenile onset (JOAG).
Ana Maria Marques, Galina Ananina, Vital Paulino Costa, José Paulo Cabral de Vasconcellos, Mônica Barbosa de Melo   +4 more
doaj   +1 more source

Keeping an Eye on Myocilin: A Complex Molecule Associated with Primary Open-Angle Glaucoma Susceptibility

Molecules, 2011
MYOC encodes a secretary glycoprotein of 504 amino acids named myocilin. MYOC is the first gene to be linked to juvenile open-angle glaucoma (JOAG) and some forms of adult-onset primary open-angle glaucoma (POAG).
Monica Barbosa De Melo, Eugênio Santana De Figueiredo, Bouzid Menaa, Vital Paulino Costa, Carolina Ayumi Braghini, Jose Paulo Cabral De Vasconcellos, Farid Menaa   +6 more
doaj   +1 more source

Glaucoma in Iran and contributions of studies in Iran to the understanding of the etiology of glaucoma

Journal of Ophthalmic & Vision Research, 2015
Epidemiologic and genetic/molecular research on glaucoma in Iran started within the past decade. A population-based study on the epidemiology of glaucoma in Yazd, a city in central Iran, revealed that 4.4% of studied individuals were affected with ...
Fatemeh Suri, Shahin Yazdani, Elahe Elahi   +2 more
doaj   +1 more source

A novel Asp380Ala mutation in the GLC1A/myocilin gene in a family with juvenile onset primary open angle glaucoma. [PDF]

Journal of Medical Genetics, 1998
Glaucoma describes a clinically and genetically heterogeneous group of diseases that result in optic neuropathy and progressive loss of visual fields. A gene for juvenile onset primary open angle glaucoma JOAG) has recently been mapped to 1q21-31. Mutations in the trabecular meshwork induced glucocorticoid response gene (TIGR, also known as myocilin or
A M, Kennan, F C, Mansergh, J H, Fingert, T, Clark, C, Ayuso, P F, Kenna, P, Humphries, G J, Farrar   +7 more
openaire   +2 more sources

Comparison between choroidal thickness in normal and glaucomatous eyes using spectral-domain optical coherence tomography

Delta Journal of Ophthalmology, 2017
Purpose The aim of this study was to compare choroidal thickness in healthy and glaucomatous eyes using spectral-domain optical coherence tomography. Patients and methods This prospective study was carried out on patients recruited from the Department ...
Mohsen A Abou Shousha, Karim M Nabil
doaj   +1 more source

Determinants of severity at presentation among young patients with early onset glaucoma

Indian Journal of Ophthalmology, 2013
Aim : The aim of this study was to evaluate the clinical, socio-economic, and demographic factors associated with the severity at presentation among juvenile primary open angle glaucoma (JOAG) patients.
Viney Gupta, Rajat M Srivastava, Ramanjit Sihota, Jasbir Kaur, Sandip Kumar, Digvijay Singh   +5 more
doaj   +1 more source

Single nucleotide polymorphism of MYOC affected the severity of primary open angle glaucoma

International Journal of Ophthalmology, 2013
AIM: To detect the mutations in two candidate genes, myocilin (MYOC) and cytochrome P450 1B1 (CYP1B1), in a Chinese family with primary open angle glaucoma (POAG).METHODS: The family was composed of three members, the parents and a daughter.
Su-Ping Cai, Wen-Han Yu, Yun Wang, Hong-Bo Cheng, Xiao-Hong Li, Ning Fan, Yan Yin, Xiao-Min Zhou, Xu-Yang Liu   +8 more
doaj   +1 more source

Screening of CYP1B1 Arg368His as predominant mutation in North Indian primary open angle glaucoma and juvenile onset glaucoma patients.

Molecular biology research communications, 2018
In India, mutations in Cytochrome P450 (CYP1B1) are a predominant cause of not only primary congenital glaucoma (PCG) but also involved in primary open angle glaucoma (POAG) and juvenile onset glaucoma (JOAG). After ethical clearance, 100 POAG patients, 30 primary angle closure glaucoma (PACG) patients and 130 ethnically matched controls were recruited
Kaur, Avneet, Vanita, Vanita, Singh, JaiRup   +2 more
openaire   +2 more sources

Association analysis of cigarette smoking with onset of primary open-angle glaucoma and glaucoma-related biometric parameters

BMC Ophthalmology, 2012
Background To date, studies on the role played by cigarette smoking in primary open-angle glaucoma (POAG) remains controversial. The current study evaluated cigarette smoking as a risk factor of POAG and its relationships with vertical cup-to-disc ratio (
Wang Degui, Huang Yuqiang, Huang Chukai, Wu Pengfei, Lin Jianwei, Zheng Yuqian, Peng Yi, Liang Yuanbo, Chen Jian-Huan, Zhang Mingzhi   +9 more
doaj   +1 more source

The effects of renal transplantation on diabetic retinopathy: Clinical course and visual outcomes

Indian Journal of Ophthalmology, 2013
Purpose: To elucidate the clinical course of diabetic retinopathy (DR) after renal transplantation (RT) in a hospital based cohort. Design: Retrospective study.
Rupak Roy, Manmath K Das, Bikramjit P Pal, Suguneswari Ganesan, Rajiv Raman, Tarun Sharma   +5 more
doaj   +1 more source