Results 121 to 130 of about 1,782 (159)

Identification of a new ‘TIGR’ mutation in a family with juvenile-onset primary open angle glaucoma

Ophthalmic Genetics, 1997
Positional mapping of families segregating for juvenile-onset primary open angle glaucoma (JOAG) has previously identified a locus (GLCIA) for this condition on the long arm of chromosome I. Recently, three mutations in the TIGR gene (Trabecular meshwork Inducible Gluco-corticoid Response protein) have been described in a total of ten familial, three ...
Diliana Stoilova, Anne H. Child, Glen Brice, Ronald P. Crick, Brian W. Fleck, Mansoor Sarfarazi   +5 more
exaly   +5 more sources

Clinical correlates to the goniodysgensis among juvenile-onset primary open-angle glaucoma patients

Graefe's Archive for Clinical and Experimental Ophthalmology, 2013
To evaluate gonioscopic features and relate them to clinical characteristics in eyes with juvenile-onset primary open-angle glaucoma (JOAG).Goniophotographs of unrelated JOAG patients, presenting between 10-40 years of age, were evaluated and compared with 60 healthy subjects in the same age group.
Viney Gupta, Rajat M. Srivastava, Aparna Rao, Manik Mittal, John H. Fingert   +4 more
exaly   +5 more sources

Novel trabecular meshwork inducible glucocorticoid response mutation in an eight-generation juvenile-onset primary open-angle glaucoma pedigree,

Ophthalmology, 1998
This study aimed to update a large kindred with juvenile-onset primary open-angle glaucoma (POAG) first described in 1940 and to identify the underlying genetic cause of the disease.Molecular genetic study of a single kindred, including clinical examination, retrospective review of clinical and family history records, linkage analysis, and mutation ...
Julia E. Richards
exaly   +5 more sources

Extent of asymmetry and unilaterality among juvenile onset primary open angle glaucoma patients

Clinical and Experimental Ophthalmology, 2011
Viney Gupta, Shikha Gupta, Munish Dhawan, Ajay Sharma, Kulwant Singh Kapoor, Ramanjit Sihota   +5 more
exaly   +4 more sources

The inheritance of juvenile onset primary open angle glaucoma

Clinical Genetics, 2016
Juvenile onset open angle glaucoma (JOAG) affects patients before 40 years of age, who present with high intraocular pressure and deep steep cupping of the optic nerve head. While it was considered to be inherited in an autosomal dominant fashion, recent studies have shown an autosomal recessive pattern as well as sporadic occurrence of the disease in ...
Viney Gupta, V. Gupta, Bindu I. Somarajan, Viney Gupta, Sunita Chaurasia, S. Kumar, Prasun Dutta, V. Gupta, V. Gupta, Ajay Sharma, Bamidele O. Tayo, Ken K. Nischal   +11 more
openalex   +3 more sources

Genetic analysis of an Indian family with members affected with juvenile-onset primary open-angle glaucoma

Ophthalmic Genetics, 2004
Glaucoma is the second leading cause of blindness. In India, approximately 1.5 million people are blind due to glaucoma. Mutations in the MYOC gene located at the GLC1A locus on chromosome 1q21-q31 have been found in patients with juvenile-onset primary open-angle glaucoma (J-POAG).
Manjunath Markandaya, T K Ramesh, Vaithinathan Selvaraju, Syril K. Dorairaj, Ravi Prakash, Jyoti Shetty, Arun Kumar   +6 more
openalex   +3 more sources

Classifying juvenile onset primary open angle glaucoma using cluster analysis

British Journal of Ophthalmology, 2019
AimTo classify unrelated patients with juvenile onset primary open angle glaucoma (JOAG) into clinically useful phenotypes using cluster analysis.MethodsOut of the 527 unrelated patients with JOAG, the study included 414 patients who had all the phenotypic characteristics required for the study. A cluster analysis was performed to classify the patients
Shweta Birla, Dinesh Gupta, Bindu I. Somarajan, Shikha Gupta, Abadh K. Chaurasia, Kishan Azmira, Viney Gupta   +6 more
openalex   +3 more sources

Bilateral Juvenile Onset Primary Open-Angle Glaucoma Among Keratoconus Patients

Journal of Glaucoma, 2013
To report the occurrence of juvenile open-angle glaucoma (JOAG) in patients with keratoconus.In this observational case series we report 6 eyes of 3 patients with keratoconus who had concomitant JOAG. Corneal topography, intraocular pressure, gonioscopic, and fundus findings were recorded for all the eyes.All 3 patients presented with corneal ectasia ...
Sahil Goel, Anita Ganger, Viney Gupta
openalex   +3 more sources

Comparisons of Risk Factors and Visual Field Changes between Juvenile-Onset and Late-Onset Primary Open-Angle Glaucoma

Ophthalmologica, 2002
<i>Purpose:</i> To identify the differences in risk factors and visual field (VF) changes between juvenile primary open-angle glaucoma (JOAG) and late-onset chronic open-angle glaucoma (COAG). <i>Methods:</i> The demographic and presenting clinical data of 27 JOAG and 30 COAG patients were retrospectively reviewed.
Yu‐Chieh Ko, Catherine Jui-Ling Liu, Joe Ching-Kuang Chou, Mei‐Ru Chen, Wen‐Ming Hsu, Jorn-Hon Liu   +5 more
openalex   +3 more sources

Long-Term Structural and Functional Outcomes of Therapy in Juvenile-Onset Primary Open-Angle Glaucoma : A Five-Year Follow-Up

Ophthalmologica, 2011
<b><i>Objective:</i></b> To evaluate long-term structural and functional changes of the optic nerve head in medically and surgically treated juvenile-onset primary open-angle glaucoma (JOAG). <b><i>Methods:</i></b> Forty-two eyes of 42 consecutive primary JOAG patients presenting between January 2000 and ...
Viney Gupta, Mary Ov, Aparna Rao, Ajay Sharma, Ramanjit Sihota   +4 more
openalex   +3 more sources