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Juvenile Dermatomyositis

Zeitschrift für Rheumatologie, 2006
Juvenile dermatomyositis (JDM) is an inflammatory multi-system disease of unknown etiology with classic involvement of the skin and striated muscles. Following a prodromal period, patients develop a progressive proximal muscle weakness. Typical skin involvement includes heliotrope rash, facial erythema, Gottron's sign and nailfold capillary ...
F, Dressler, H-I, Huppertz
openaire   +2 more sources

Juvenile dermatomyositis

2013
Juvenile dermatomyositis (JDM) is a systemic, inflammatory, idiopathic disease, mainly affecting the skin and the muscles, starting before the age of 16, with an incidence around one case per 1 million children. Some patients display typical features of JDM without skin involvement, or even without muscle involvement; however, both tissues are affected
Pierre, Quartier, Romain K, Gherardi
openaire   +2 more sources

Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.

Current pediatric reviews, 2021
BACKGROUND Juvenile dermatomyositis is the most common inflammatory myopathy in the pediatric age group and a major cause of mortality and morbidity in individuals with childhood rheumatic diseases.
A. Leung   +4 more
semanticscholar   +1 more source

Autologous CD19‐Targeting CAR T Cells in a Patient With Refractory Juvenile Dermatomyositis

Arthritis & Rheumatology
The aim of this study is to report the safety and efficacy of CD19‐targeting chimeric antigen receptor (CAR) T cells in a child with refractory juvenile dermatomyositis (JDM).
R. Nicolai   +15 more
semanticscholar   +1 more source

Juvenile Dermatomyositis

Rheumatic Disease Clinics of North America, 1991
Juvenile dermatomyositis is a relatively rare, multisystem disease characterized by a nonsuppurative myositis which causes symmetrical weakness, rash and vasculitis; this last can affect the gastrointestinal tract and the myocardium. Late development of calcinosis is seen in approximately two thirds of patients.
openaire   +3 more sources

Monoclonal antibody targeting IFNβ for the treatment of NXP2-positive ulcerative juvenile dermatomyositis.

Pediatrics
This report outlines the case of a 9-year-old girl with severe anti-nuclear matrix protein 2 antibody-positive juvenile dermatomyositis presenting with disease refractory to multiple traditional therapies.
Justina Guirguis   +6 more
semanticscholar   +1 more source

Treatment with Janus kinase inhibitors in juvenile dermatomyositis: A review of the literature.

Seminars in Arthritis & Rheumatism
BACKGROUND/OBJECTIVES Janus kinase (JAK) inhibitors have been increasingly used in the treatment of juvenile dermatomyositis (JDM). This review aims to comprehensively analyze previous studies concerning the utilization of JAK inhibitors in JDM patients.
S. Şener   +3 more
semanticscholar   +1 more source

Current Evidence for Janus Kinase Inhibitors in Adult and Juvenile Dermatomyositis and Key Comparisons

Expert Opinion on Pharmacotherapy
Introduction Adult dermatomyositis (DM) and juvenile dermatomyositis (JDM) are rare autoimmune diseases with characteristic skin rashes, weakness, and other systemic features. Upregulated interferon signaling has been consistently described in both adult
R. Wallwork, Julie J. Paik, Hanna Kim
semanticscholar   +1 more source

Janus kinase inhibition in induction treatment of anti‐MDA5 juvenile dermatomyositis‐associated rapidly progressive interstitial lung disease

International Journal of Rheumatic Diseases, 2021
Tofacitinib has an important role in pediatric rapidly progressive interstitial lung disease (ILD) associated with juvenile dermatomyositis (JDM), an otherwise potentially fatal condition. It may be useful in induction of remission and can be used safely
Poh Lin Pauline Chan Ng   +7 more
semanticscholar   +1 more source

Angiokeratomas in Juvenile Dermatomyositis

Pediatric Dermatology, 1999
Abstract: Juvenile dermatomyositis (JDM) is an uncommon disease that features muscle weakness, a characteristic rash, and vascular changes in skin, muscle, and other organs. We report a patient with JDM who developed multiple angiokeratomas, one of which was calcified.
P L, Shannon, M J, Ford
openaire   +2 more sources

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