Results 91 to 100 of about 46,368 (260)

Disruption of reproductive and thyroid endocrine systems in zebrafish following early life and whole life cycle exposure to low-dose norgestrel

open access: yesEcotoxicology and Environmental Safety
Norgestrel (NGT), a synthetic progestin, is frequently detected in aquatic environments and known to disrupt fish endocrine systems. In this study, zebrafish embryos were exposed to low NGT concentrations (9 and 66 ng/L) for 90 days post-fertilization ...
Shuyan Mai   +9 more
doaj   +1 more source

EEG findings in SERAC1‐related MEGD(H)EL syndrome

open access: yes
Epileptic Disorders, EarlyView.
Apurva Patel, Dalila Lewis, Thomas Koch
wiley   +1 more source

The Natural History of Residual and Recurrent Disease in Advanced Juvenile Nasopharyngeal Angiofibroma: A Systematic Review

open access: yesThe Laryngoscope, EarlyView.
Residual and recurrent disease in advanced juvenile nasopharyngeal angiofibromas (JNAs) demonstrate spontaneous involution, reduction in size, or long‐term stability following initial treatment in 95% of patients. In this systematic review of 131 patients with advanced JNA, only 2% of patients demonstrated disease progression during surveillance, but ...
Shivani Angelique Kumar   +2 more
wiley   +1 more source

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

open access: yesMedicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang   +3 more
wiley   +1 more source

Endoscopic small bowel therapies for type 2 diabetes

open access: yesNutrition in Clinical Practice, EarlyView.
Abstract Type 2 diabetes is a global epidemic despite current medical treatments. Many patients are not responsive to medications, and patients with obesity are hesitant about bariatric surgery. Studies investigating the metabolic effects of Roux‐en‐Y gastric bypass have increasingly demonstrated that the duodenum plays a key role in the ...
Roma Patel   +4 more
wiley   +1 more source

Aphid alarm pheromone (E)‐β‐farnesene: mechanisms, applications, and challenges in pest management

open access: yesNew Plant Protection, EarlyView.
This review highlights the advances in the application of the aphid alarm pheromone (E)‐β‐farnesene (EβF) for pest management. It focuses on smart delivery systems, molecular optimization, synthetic biology, and integration with digital agriculture. Additionally, it discusses key challenges and future directions for enhancing stability, field efficacy,
Yi Yan   +3 more
wiley   +1 more source

Effects of the use of growth hormone in children and adolescents with juvenile idiopathic arthritis: a systematic review

open access: yesRevista Brasileira de Reumatologia
Introduction: Children with juvenile idiopathic arthritis (JIA) often have impaired growth and short stature. There is evidence that the therapeutic use of growth hormone (GH) is useful and safe in these patients. Objective: To analyze the effects of GH
Renan Bazuco Frittoli   +5 more
doaj   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

open access: yesObesity, EarlyView.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter   +14 more
wiley   +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

open access: yesThe Journal of Pathology, EarlyView.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan   +9 more
wiley   +1 more source

A Teenage Guitarist's Swollen Fingers

open access: yes
JEADV Clinical Practice, EarlyView.
Maho Matsuo, Hiroaki Iwata
wiley   +1 more source

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