A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis [PDF]
G3: Genes, Genomes, Genetics, 2016 Multiple aspects of Drosophila oogenesis, including germline stem cell activity, germ cell differentiation, and follicle survival, are regulated by the steroid hormone ecdysone.
Elizabeth T. Ables +4 more
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Ecdysone coordinates plastic growth with robust pattern in the developing wing
eLife, 2022 Animals develop in unpredictable, variable environments. In response to environmental change, some aspects of development adjust to generate plastic phenotypes.
André Nogueira Alves +4 more
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Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis [PDF]
eLife, 2014 Despite their fundamental importance for body size regulation, the mechanisms that stop growth are poorly understood. In Drosophila melanogaster, growth ceases in response to a peak of the molting hormone ecdysone that coincides with a nutrition ...
Takashi Koyama +4 more
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Impact of steroid hormone signals on
Cell Division, 2009 Metamorphosis of Drosophila involves proliferation, differentiation and death of larval tissues in order to form the adult fly. The major steroid hormone implicated in the larval-pupal transition and adult tissue modelling is ecdysone.
Quinn Leonie, Cranna Nicola
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Identification of Ecdysone Hormone Receptor Agonists as a Therapeutic Approach for Treating Filarial Infections. [PDF]
PLoS Neglected Tropical Diseases, 2016 BACKGROUND:A homologue of the ecdysone receptor has previously been identified in human filarial parasites. As the ecdysone receptor is not found in vertebrates, it and the regulatory pathways it controls represent attractive potential chemotherapeutic ...
Amruta S Mhashilkar +8 more
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The insulin and ecdysone pathways as regulators of diapause termination: transcriptional and protein insights from Pieris napi [PDF]
BMC GenomicsInsect diapause is a pre-programmed alternative developmental pathway induced to survive adverse environmental conditions and is characterized by an absence of development, metabolic suppression and increased stress resistance.
Philip Süess +6 more
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Azadirachtin disrupts ecdysone signaling and alters sand fly immunity [PDF]
Parasites & VectorsBackground Leishmaniasis is a group of neglected vector-borne diseases transmitted by phlebotomine sand flies. Leishmania parasites must overcome various defenses in the sand fly midgut, including the insects’s immune response.
Cecilia Stahl Vieira +4 more
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BMC Biology, 2018 Background Drosophila is a powerful model for the study of factors modulating innate immunity. This study examines the effect of water-loss dehydration on innate immune responsiveness in the Drosophila renal system (Malpighian tubules; MTs), and how this
Wenjing Zheng +6 more
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Ecdysone signaling induces two phases of cell cycle exit in Drosophila cells
Biology Open, 2016 During development, cell proliferation and differentiation must be tightly coordinated to ensure proper tissue morphogenesis. Because steroid hormones are central regulators of developmental timing, understanding the links between steroid hormone ...
Yongfeng Guo +4 more
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Proceedings of the National Academy of Sciences of the United States of America, 2018 Wei Song, Zheng Li, Wenliang Qian
exaly +2 more sources