Results 41 to 50 of about 8,028 (164)

Function and Evolution of Nuclear Receptors in Environmental-Dependent Postembryonic Development

Frontiers in Cell and Developmental Biology, 2021
Nuclear receptors (NRs) fulfill key roles in the coordination of postembryonal developmental transitions in animal species. They control the metamorphosis and sexual maturation in virtually all animals and by that the two main environmental-dependent ...
Jan Taubenheim, Constantin Kortmann, Sebastian Fraune   +2 more
doaj   +1 more source

Bicistronic Expression of Ecdysone-Inducible Receptors in Mammalian Cells

BioTechniques, 2001
The recent emergence of inducible expression systems for mammalian cells has greatly facilitated the in vivo analysis of gene function. The ecdysone-inducible expression system is particularly attractive because of (i) extremely low basal expression and ...
Denise L. Wyborski, John C. Bauer, Peter Vaillancourt   +2 more
doaj   +1 more source

New reporter gene assays for detecting natural and synthetic molting hormone agonists using yeasts expressing ecdysone receptors of various insects

FEBS Open Bio, 2017
Synthetic nonsteroidal ecdysone agonists, a class of insect growth regulators (IGRs), target the ecdysone receptor (EcR), which forms a heterodimer with ultraspiracle (USP) to transactivate ecdysone response genes.
Sayoko Ito‐Harashima, Mai Matsuura, Masanobu Kawanishi, Yoshiaki Nakagawa, Takashi Yagi   +4 more
doaj   +1 more source

Ecdysone signaling induces two phases of cell cycle exit in Drosophila cells

Biology Open, 2016
During development, cell proliferation and differentiation must be tightly coordinated to ensure proper tissue morphogenesis. Because steroid hormones are central regulators of developmental timing, understanding the links between steroid hormone ...
Yongfeng Guo, Kerry Flegel, Jayashree Kumar, Daniel J. McKay, Laura A. Buttitta   +4 more
doaj   +1 more source

Economical Analysis of a Pressurized Fluid-Based Process Applied for Phytochemicals Recovery in a Sustainable Biorefinery Concept for Brazilian Ginseng Roots

Chemical Engineering Transactions, 2016
A growing number of technologies are being developed in order to produce different high added value products, such as phytochemicals, ethanol and other chemicals from biomass, representing an important trend that needs to be evaluated.
J. Albarelli, R. Vardanega, N. Wilkins, D. Santos, F. Marechal, M. Meireles   +5 more
doaj   +1 more source

Dehydration triggers ecdysone-mediated recognition-protein priming and elevated anti-bacterial immune responses in Drosophila Malpighian tubule renal cells

BMC Biology, 2018
Background Drosophila is a powerful model for the study of factors modulating innate immunity. This study examines the effect of water-loss dehydration on innate immune responsiveness in the Drosophila renal system (Malpighian tubules; MTs), and how this
Wenjing Zheng, Florentina Rus, Ana Hernandez, Ping Kang, William Goldman, Neal Silverman, Marc Tatar   +6 more
doaj   +1 more source

A Drosophila ecdysone-deficient model to assess the endocrine disruptor activity of Bisphenol A

Ecotoxicology and Environmental Safety
Bisphenol A (BPA) is a well characterized endocrine disruptor that interferes with the activity of a variety of nuclear receptors. For this reason, BPA has the potential to impact the function of the endocrine system and alter cellular physiology.
Patricia Vega-Cuesta, Diego Pulido, David Abia, Sandra Herrera, Ana Lopez-Varea, Ana Ruiz-Gómez, Paloma Fernández-Freire, Ana Peropadre, Jose F. de Celis   +8 more
doaj   +1 more source

Effect of blood components, abdominal distension, and ecdysone therapy on the ultrastructural organization of posterior midgut epithelial cells and perimicrovillar membranes in Rhodnius prolixus

Memorias do Instituto Oswaldo Cruz, 2004
The effects of blood components, nerve-cord severance, and ecdysone therapy on the posterior midgut epithelial cells of 5th-instar Rhodnius prolixus nymphs 10 days after feeding were analyzed by transmission electron microscopy. Cutting the nerve-cord of
JM Albuquerque-Cunha, CB Mello, ES Garcia, P Azambuja, W de Souza, MS Gonzalez, NFS Nogueira   +6 more
doaj   +1 more source

Ecdysone signaling acts as a regulator of immunity and microbiota balance, shaping Leishmania infantum infection in Phlebotomus perniciosus

Frontiers in Immunology
BackgroundThe steroid hormone ecdysone, acting through its nuclear receptor (EcR), is a key regulator of insect development and reproduction and also contributes to immune regulation and gut microbiota homeostasis.
Cecilia Stahl Vieira, Cecilia Stahl Vieira, Marco Salvemini, Petr Volf, Erich Loza Telleria   +4 more
doaj   +1 more source

A Drosophila CRISPR/Cas9 Toolkit for Conditionally Manipulating Gene Expression in the Prothoracic Gland as a Test Case for Polytene Tissues

G3: Genes, Genomes, Genetics, 2018
Targeting gene function with spatial or temporal specificity is a key goal in molecular genetics. CRISPR-Cas9 has greatly facilitated this strategy, but some standard approaches are problematic.
Nhan Huynh, Jie Zeng, Wen Liu, Kirst King-Jones   +3 more
doaj   +1 more source