Results 41 to 50 of about 23,839 (265)
Steroid hormone control of cell death and cell survival: molecular insights using RNAi.
PLoS Genetics, 2009 The insect steroid hormone ecdysone triggers programmed cell death of obsolete larval tissues during metamorphosis and provides a model system for understanding steroid hormone control of cell death and cell survival.
Suganthi Chittaranjan +5 more
doaj +1 more source
The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development. [PDF]
, 2015 Schistosomiasis affects millions of people in developing countries and is responsible for more than 200,000 deaths annually. Because of toxicity and limited spectrum of activity of alternatives, there is effectively only one drug, praziquantel, available
Barnard, Andrew H +6 more
core +3 more sources
Molecular evidence for a functional ecdysone signaling system in Brugia malayi. [PDF]
PLoS Neglected Tropical Diseases, 2010 BACKGROUND:Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles.
George Tzertzinis +7 more
doaj +1 more source
Mechanisms of transcriptional regulation of ecdysone response
Вавиловский журнал генетики и селекции, 2019 The mechanisms of ecdysone-dependent expression have been studied for many decades. Initially, the activation of individual genes under the influence of ecdysone was studied on the model of polythene chromosomes from salivary glands of Drosophila ...
M. Yu. Mazina, N. E. Vorobyeva
doaj +1 more source
TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila [PDF]
, 2013 TDP-43 proteinopathy is strongly implicated in the pathogenesis of amyotrophic lateral sclerosis and related neurodegenerative disorders. Whether TDP-43 neurotoxicity is caused by a novel toxic gain-of-function mechanism of the aggregates or by a loss of
Adachi, Yoshitsugu +13 more
core +3 more sources
Development, 2020 The activation of a neuroendocrine system that induces a surge in steroid production is a conserved initiator of the juvenile-to-adult transition in many animals.
Christian F. Christensen +6 more
semanticscholar +1 more source
Scientific Reports, 2020 Insect pathogens have adopted an array of mechanisms to subvert the immune pathways of their respective hosts. Suppression may occur directly at the level of host–pathogen interactions, for instance phagocytic capacity or phenoloxidase activation, or at ...
Eric Kenney +5 more
semanticscholar +1 more source
Ecdysteroids: A novel class of anabolic agents? [PDF]
, 2015 Increasing numbers of dietary supplements with ecdysteroids are marketed as “natural anabolic agents”. Results of recent studies suggested that their anabolic effect is mediated by estrogen receptor (ER) binding. Within this study the anabolic potency of
BOTRE', Francesco +5 more
core +2 more sources
Bab2 Functions as an Ecdysone-Responsive Transcriptional Repressor during Drosophila Development
Cell Reports, 2020 Summary: Drosophila development is governed by distinct ecdysone steroid pulses that initiate spatially and temporally defined gene expression programs. The translation of these signals into tissue-specific responses is crucial for metamorphosis, but the
Jianli Duan +7 more
doaj +1 more source
Increased insulin/insulin growth factor signaling advances the onset of metamorphosis in Drosophila. [PDF]
PLoS ONE, 2009 Mechanisms by which attainment of specific body sizes trigger developmental transitions to adulthood (e.g. puberty or metamorphosis) are incompletely understood.
Magdalena A Walkiewicz, Michael Stern
doaj +1 more source