The ecdysone receptor regulates several key physiological factors in Anopheles funestus
Malaria Journal, 2022 Background Malaria is a devastating disease, transmitted by female Anopheles mosquitoes infected with Plasmodium parasites. Current insecticide-based strategies exist to control the spread of malaria by targeting vectors.
Surina Maharaj +6 more
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Insects, 2022 In the present study, we observed a 58% decrease in the fecundity of Drosophila melanogaster, after treatment with the cyromazine. To further elucidate the effects of cyromazine on reproduction, we counted the number of both germline stem cells (GSCs ...
Muhammad Zaryab Khalid +4 more
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Spider Hemocyanin Binds Ecdysone and 20-OH-Ecdysone [PDF]
Journal of Biological Chemistry, 1999 Fluorescence quenching studies and binding experiments with [(3)H]ecdysone reveal that the respiratory protein, hemocyanin, of the tarantula Eurypelma californicum binds ecdysone. The binding constant for ecdysone ranges between 0.5 and 5 mM, indicating a low affinity binding.
E, Jaenicke, R, Föll, H, Decker
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Pigment dispersing factor regulates ecdysone biosynthesis via bombyx neuropeptide G protein coupled receptor-B2 in the prothoracic glands of Bombyx mori. [PDF]
PLoS ONE, 2014 Ecdysone is the key hormone regulating insect growth and development. Ecdysone synthesis occurs in the prothoracic glands (PGs) and is regulated by several neuropeptides.
Masatoshi Iga +3 more
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Molecular evidence for a functional ecdysone signaling system in Brugia malayi. [PDF]
PLoS Neglected Tropical Diseases, 2010 BACKGROUND:Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles.
George Tzertzinis +7 more
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Novel roles for ecdysone receptor in the Drosophila germline
, 2023 Oogenesis, the process by which a viable egg is produced, demands carefully coordinated communication between somatic and germ cell populations, relying on both local and systemic factors such as steroid hormones for signaling. In Drosophila, the steroid
NC DOCKS at East Carolina University +1 more
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Steroid hormone control of cell death and cell survival: molecular insights using RNAi.
PLoS Genetics, 2009 The insect steroid hormone ecdysone triggers programmed cell death of obsolete larval tissues during metamorphosis and provides a model system for understanding steroid hormone control of cell death and cell survival.
Suganthi Chittaranjan +5 more
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Bab2 Functions as an Ecdysone-Responsive Transcriptional Repressor during Drosophila Development
Cell Reports, 2020 Summary: Drosophila development is governed by distinct ecdysone steroid pulses that initiate spatially and temporally defined gene expression programs. The translation of these signals into tissue-specific responses is crucial for metamorphosis, but the
Jianli Duan +7 more
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Increased insulin/insulin growth factor signaling advances the onset of metamorphosis in Drosophila. [PDF]
PLoS ONE, 2009 Mechanisms by which attainment of specific body sizes trigger developmental transitions to adulthood (e.g. puberty or metamorphosis) are incompletely understood.
Magdalena A Walkiewicz, Michael Stern
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Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis
eLife, 2014 Despite their fundamental importance for body size regulation, the mechanisms that stop growth are poorly understood. In Drosophila melanogaster, growth ceases in response to a peak of the molting hormone ecdysone that coincides with a nutrition ...
Takashi Koyama +4 more
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