Results 171 to 180 of about 10,033 (195)

Juvenile localized scleroderma: Is it a benign disease?

Revista Colombiana de Reumatología (English Edition), 2017
Abstract Introduction Juvenile localized scleroderma is a polymorphic disease. It is more prevalent in girls and has a significant morbidity. Extra-cutaneous involvement is common, and polyautoimmunity can reach 7%. The clinical characteristics of this disease in Colombian patients are currently unknown.
Christine Arango, Clara Malagón, María del Pilar Gómez, Catalina Mosquera, Ricardo Yépez, Tatiana González, Camilo Vargas   +6 more
openaire   +2 more sources

Preliminary Evidence on Abatacept Safety and Efficacy in Refractory Juvenile Localized Scleroderma.

Rheumatology, 2020
OBJECTIVES To evaluate the safety and efficacy of abatacept treatment for refractory juvenile localized scleroderma (jLS) in a retrospective study. METHODS A multicentre cohort study was performed to evaluate jLS subjects treated with abatacept with ...
Suzanne C. Li, K. Torok, Sarah S Ishaq, M. Buckley, B. Edelheit, K. Ede, Christopher Liu, C. Rabinovich   +7 more
semanticscholar   +1 more source

Juvenile Localized and Systemic Scleroderma

2016
Juvenile localized scleroderma and juvenile systemic sclerosis (jSSc) are sclerotic disorders which differ greatly in their extent of involvement and prognosis. Juvenile localized scleroderma, also called morphea, involves the skin and subcutaneous tissues. It occurs in 4.7–20 per 100,000 children and is ten times more frequent than jSSc. Lesions range
Lauren V. Graham, Amy S. Paller, Ivan Foeldvari   +2 more
openaire   +1 more source

OP0292 Therapeutic Strategies for Juvenile Localized Scleroderma

Annals of the Rheumatic Diseases, 2015
Background Juvenile localized scleroderma (JLS) is a chronic inflammatory fibrosing disorder with numerous disease subtypes, results in deep tissue atrophy, limited functional capacity. Treatment of jLS is still contraversal, ranges from topical skin management to immunosuppressive therapy (IST).
M. Osminina, N. Geppe, O. Spitonkova, J. Kostina, E. Afonina, G. Tougarinova   +5 more
openaire   +1 more source

Development of minimum standards of care for juvenile localized scleroderma

European Journal of Pediatrics, 2018
Juvenile localized scleroderma (jLS), also known as morphea, is an orphan disease. Pediatric guidelines regarding diagnosis, assessment, and management are lacking.Our objective was to develop minimum standards of care for diagnosis, assessment, and management of jLS. A systematic review was undertaken to establish the pediatric evidence for assessment
T. Constantin, I. Foeldvari, C. Pain, Anna Palinkas, P. Höger, M. Moll, D. Nemkova, L. Weibel, Melinda Laczkovszki, P. Clements, K. Torok   +10 more
semanticscholar   +4 more sources

New Developments in Juvenile Systemic and Localized Scleroderma

Rheumatic Disease Clinics of North America, 2013
Juvenile localized scleroderma (jLS) and juvenile systemic sclerosis (jSS) are both orphan diseases, with jLS around 10 times more frequent than jSS. In recent years the time gap between the appearance of symptoms and diagnosis has become significantly shorter.
openaire   +2 more sources

Juvenile Localized Scleroderma

2011
Juvenile localized scleroderma (JLS), known as morphea, comprises a group of conditions which involve essentially the skin and subcutaneous tissues. They have various features and range from very small plaques to extensive fibrotic lesions which may cause significant functional changes and cosmetic deformities.
openaire   +1 more source

[Juvenile localized scleroderma].

Dermatologie (Heidelberg, Germany)
Juvenile scleroderma, often referred to as juvenile localized scleroderma or "morphea", is a rare inflammatory disease of the skin and skin-related structures, accompanied by local sclerosis and tissue fibrosis. Depending on the clinical manifestation, four different subtypes can be defined: limited, generalized, linear, and mixed.
Timmy, Strauss, Claudia, Günther, Normi, Brück   +2 more
openaire   +1 more source

[Clinical characteristics of patients with juvenile localized scleroderma].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2011
To investigate the clinical characteristics of juvenile localized scleroderma (JLS).The clinical data of 100 outpatients with JLS who were admitted to PUMC Hospital from 2000 to 2008 were retrospectively analyzed.Of a total of 100 cases, 51 (51%) were confirmed as linear scleroderma, 26 (26%) as plaque morphea, 26 (26%) as deep morphea, 12 (12%) as ...
Qiu-Ning, Sun, Wei, Du, Bin, Hu, Pai, Liu, Xie, Yuan   +4 more
openaire   +1 more source

SP0206 Juvenile Localized Scleroderma: Assessing Disease Activity and Treatment

Annals of the Rheumatic Diseases, 2015
During the recent years various methods for the clinical monitoring of localized scleroderma have been developed but none has been already validated in large cohort of patients. Semi quantitative scoring methods, such as the Localized Scleroderma Severity Index (LoSSI), have been proposed.
openaire   +1 more source