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Preliminary Evidence on Abatacept Safety and Efficacy in Refractory Juvenile Localized Scleroderma.
Rheumatology, 2020OBJECTIVES To evaluate the safety and efficacy of abatacept treatment for refractory juvenile localized scleroderma (jLS) in a retrospective study. METHODS A multicentre cohort study was performed to evaluate jLS subjects treated with abatacept with ...
Suzanne C. Li +7 more
semanticscholar +1 more source
The burden of extracutaneous manifestations in juvenile localized scleroderma: A literature review.
Autoimmunity ReviewsJuvenile Localized Scleroderma (JLS) is an autoimmune disease leading to fibrosis of skin and subcutaneous tissues affecting children, that is characterized by extracutaneous manifestations (ECM) in about 20 % of patients. JLS and ECM can cause severe disabilities, potentially impacting patients' quality of life (QoL). We aimed to systematically review
Ilaria Liguoro +2 more
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New Developments in Juvenile Systemic and Localized Scleroderma
Rheumatic Disease Clinics of North America, 2013Juvenile localized scleroderma (jLS) and juvenile systemic sclerosis (jSS) are both orphan diseases, with jLS around 10 times more frequent than jSS. In recent years the time gap between the appearance of symptoms and diagnosis has become significantly shorter.
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OP0292 Therapeutic Strategies for Juvenile Localized Scleroderma
Annals of the Rheumatic Diseases, 2015Background Juvenile localized scleroderma (JLS) is a chronic inflammatory fibrosing disorder with numerous disease subtypes, results in deep tissue atrophy, limited functional capacity. Treatment of jLS is still contraversal, ranges from topical skin management to immunosuppressive therapy (IST).
O. Spitonkova +5 more
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Non-invasive imaging and clinical skin scores in juvenile localized scleroderma
Rheumatology, 2023Abstract Objectives To evaluate whether in juvenile localized scleroderma (JLS), non-invasive imaging can differentiate affected from non-affected skin and whether imaging correlates with a validated skin score [Localised Scleroderma Cutaneous Assessment Tool (LoSCAT)].
Clare E Pain +9 more
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Juvenile Localized Scleroderma
2011Juvenile localized scleroderma (JLS), known as morphea, comprises a group of conditions which involve essentially the skin and subcutaneous tissues. They have various features and range from very small plaques to extensive fibrotic lesions which may cause significant functional changes and cosmetic deformities.
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A long-term follow-up study of methotrexate in juvenile localized scleroderma (morphea)
Journal of the American Academy of Dermatology, 2012Recent studies report that methotrexate (MTX) is beneficial in the treatment of juvenile localized scleroderma (JLS) but little is known about its long-term effectiveness.We assessed the therapeutic role of MTX in children with JLS who were followed up for a prolonged period.A cohort of patients with JLS, previously enrolled in a double-blind ...
Zulian F +9 more
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42086 Disease Course and Risk of Relapse in Juvenile Localized Scleroderma
Journal of American Academy of Dermatology, 2023B. Rankin +7 more
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Esophageal involvement in juvenile localized scleroderma: a pilot study.
Clinical and experimental rheumatology, 2007To evaluate the esophageal involvement in patients with juvenile localized scleroderma (JLS).A cohort of patients with JLS underwent esophageal stationary manometry to evaluate esophageal motility and lower esophageal sphincter (LES) function, distal esophagus 24-hour pH-monitoring to detect gastroesophageal reflux (GER) and upper gastrointestinal (GI)
GUARISO, GRAZIELLA +5 more
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