Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus
Neuropsychiatric disorders in juvenile-onset systemic lupus erythematosus (SLE) stay in the focus of attention in recent decades due to significant influence of CNS lesions on SLE course in general, necessity to optimize therapeutic interventions and ...
M. I. Kaleda, I. P. Nikishina
doaj +1 more source
Autoimmune gastrointestinal complications in patients with Systemic Lupus Erythematosus: case series and literature review [PDF]
The association of systemic lupus erythematosus (SLE) with gastrointestinal autoimmune diseases is rare, but has been described in the literature, mostly as case reports.
Agmon-Levin N +101 more
core +1 more source
Autoantibody Response Toward Chromatin in Patients With Juvenile Idiopathic Arthritis
Objective Patients with juvenile idiopathic arthritis (JIA) frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in patients with JIA remains elusive.
Viola Pitkänen +13 more
wiley +1 more source
The presence of high mobility group box-1 and soluble receptor for advanced glycation end-products in juvenile idiopathic arthritis and juvenile systemic lupus erythematosus [PDF]
BACKGROUND: The involvement of high mobility group box-1 (HMGB1) in various inflammatory and autoimmune diseases has been documented but clinical trials on the contribution of this pro-inflammatory alarmin in children with juvenile idiopathic ...
Bobek, Dubravka +4 more
core +1 more source
Rituximab therapy for juvenile-onset systemic lupus erythematosus [PDF]
Rituximab (RTX), an anti-CD20 monoclonal antibody, has been proposed for use in the therapy of systemic lupus erythematosus (SLE). We present the initial long-term experience of the safety and efficacy of rituximab for treatment of SLE in children.
Nwobi, Obioma +4 more
openaire +2 more sources
P048 Juvenile systemic lupus erythematosus, what specificities?
Abstract Background Juvenile systemic lupus erythematosus (J-SLE) is a chronic autoimmune disease characterized by multi-visceral involvement with an unpredictable prognosis. The diagnosis is usually made in young women between the ages of 20 and 40, however, it can set in at any age and will be ...
Kamelia Okka +5 more
openaire +1 more source
Serum Cytokine Profiling Differentiates Underlying Diseases in Cytokine Storm Syndrome
Serum cytokine profiling was performed using Luminex (48 cytokines) and ELISA (5 cytokines). Assessment of key cytokines (IFN‐α, IL‐18, IL‐6, CXCL9) delineated five dominant inflammatory patterns: I, IFN‐α–dominant CSS; II, IL‐18–dominant CSS; III, IL‐6–dominant CSS; IV, IFN‐γ–dominant CSS; and V, IL‐6 & IFN‐γ intermediate CSS.
Shuya Kaneko +42 more
wiley +1 more source
International validation of a urinary biomarker panel for identification of active lupus nephritis in children. [PDF]
Conventional markers of juvenile-onset systemic lupus erythematosus (JSLE) disease activity fail to adequately identify lupus nephritis (LN). While individual novel urine biomarkers are good at detecting LN flares, biomarker panels may improve diagnostic
Beresford, MW +15 more
core +2 more sources
Juvenile Systemic Lupus Erythematosus in 60 Saudi Children
A ten-year retrospective analysis of the clinical features and survival of 60 Saudi children with systemic lupus erythematosus (SLE) was made. All the patients fulfilled the 1982 American College of Rheumatologyâs revised criteria for SLE and had had the disease at or before the age of 16 years.
S, Bahabri +6 more
openaire +2 more sources
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun +4 more
wiley +1 more source

