OBJECTIVE: To characterize neurological involvement in juvenile systemic lupus erythe-matosus. METHOD: The charts of all patients with the diagnosis of systemic lupus erythematosus before the age of 16 years, followed at the Rheumatology Unit of Pequeno ...
Mônica Jaques Spinosa +6 more
doaj +1 more source
Reproductive health aspects in men with idiopathic inflammatory myopathy: a multicenter study [PDF]
OBJECTIVE: To evaluate reproductive health of males with idiopathic inflammatory myopathies (IIM), and comparing them with a control group. METHODS: Demographic data, urologic evaluation (including pubertal parameters and sexual/erectile function ...
Bonfá, Eloisa Silva Dutra de Oliveira +10 more
core +2 more sources
International validation of a urinary biomarker panel for identification of active lupus nephritis in children. [PDF]
Conventional markers of juvenile-onset systemic lupus erythematosus (JSLE) disease activity fail to adequately identify lupus nephritis (LN). While individual novel urine biomarkers are good at detecting LN flares, biomarker panels may improve diagnostic
Beresford, MW +15 more
core +2 more sources
Case Report: Novel UNC93B1 variant causes rheumatoid arthritis and interstitial pneumonia
BackgroundUNC93B1 is a transmembrane protein essential for regulating toll-like receptors (TLRs). Pathogenic variants in human UNC93B1 have recently been described in a limited number of patients with childhood systemic lupus erythematosus and chilblain ...
Tingyan He +6 more
doaj +1 more source
Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE)
Systemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15–20% of SLE patients develop the disease during childhood or adolescence (juvenile-onset SLE/jSLE).
Valentina Natoli +3 more
doaj +1 more source
Unmet Needs in the Pathogenesis and Treatment of Systemic Lupus Erythematosus [PDF]
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with a prevalence of approximately 1 in 1000. Over the last 30 years, advances in treatment such as use of corticosteroids and immunosuppressants have improved life expectancy and ...
Bakshi, J +3 more
core +1 more source
Heterogeneous lupus‐specific lesions and treatment outcome, in a single patient, over a period of time [PDF]
The report highlights the importance of strict clinico-histological correlations when skin biopsies are performed in diagnostic doubt in systemic lupus erythematosus.
Agostini, Patrick +5 more
core +2 more sources
Renal Disease in ROSAH Syndrome Masquerading as Lupus Nephritis: A Case Report and Cohort Analysis
ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome is a rare, autosomal dominant autoinflammatory disorder caused by gain-of-function mutations in ALPK1.
Anirban Ganguli +4 more
doaj +1 more source
Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System [PDF]
Glucocorticoids regulate fundamental processes of the human body and control cellular functions such as cell metabolism, growth, differentiation, and apoptosis.
Agarwal +268 more
core +1 more source
Juvenile-onset systemic lupus erythematosus in Malay children
[No abstract available].
Ali S, Jawad, Wan Zuraida W A, Hamid
openaire +2 more sources

