Results 61 to 70 of about 160,253 (303)
Advanced Science, EarlyView.IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou +11 more
wiley +1 more source
Advanced Science, EarlyView.A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou +18 more
wiley +1 more source
JUVENILE LAW REFORM - RETROSPECTIVE AND CONTEMPORARY PERSPECTIVES [PDF]
ProbacjaThe system of Polish law on juvenile proceedings has undergone significant changes over the years. The result of these changes is the currently in force Act of 9 June 2022 on the support and re-socialisation of minors, which replaced, after 40 years, the
Edyta Mucha
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Advanced Science, EarlyView.Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang +6 more
wiley +1 more source
La temática de las adicciones juveniles y el INJ
, 1991 La Colección GEPOJU - CENID del IIGG reúne un amplio archivo con documentos históricos elaborados durante el periodo 1980-2006 en Argentina, América Latina y el Caribe y, España, por: Organismos Gubernamentales de Juventud; Organismos Gubernamentales NO ...
Ministerio de Salud y Acción Social
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Os menores no Porto : entre o desamparo e o crime (1880-1911)
Ler História, 2007 From the last quarter of the 19th Century to World War I, important reflections were produced around the situation of the juvenile delinquents and in moral danger, a complex problem that included in its discussion an international multidisciplinal elite.
Maria José Moutinho Santos
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Journal of Rheumatic Diseases, 2022 Juvenile dermatomyositis (JDM) is a systemic capillary vasculopathy. Patients present with proximal muscle weakness, raised muscle enzymes, and pathognomic skin rashes such as heliotrope rash, Gottron's papules. Main complications are calcinosis, lipodystrophy, osteoporosis. Complement-mediated damage of vessels is a major mechanism. Magnetic resonance
openaire +3 more sources
Guión : portavoz de las Falanges Juveniles de Franco: Año I Número 1 - 1946 febrero 1
, 1946 Copia digital.
core
Advanced Science, EarlyView.Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian +10 more
wiley +1 more source
Small and large spatial scale coexistence of ctenid spiders in a neotropical forest (French Guiana)
Tropical Zoology, 2018 While spiders constitute the most abundant and diverse arthropods in many habitats, they remained under-studied, especially in tropical rainforests. The goal of this study is to assess the spatial distribution of the spider family Ctenidae by assessing ...
Julien Pétillon +3 more
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