Results 81 to 90 of about 394,901 (310)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang   +7 more
wiley   +1 more source

Założenia modelowe i standardy międzynarodowe dotyczące nieletnich sprawców przestępstw

open access: yesArchiwum Kryminologii, 2008
Artykuł analizuje międzynarodowe standardy postępowania z nieletnimi sprawcami przestępstw. Autorka tekstu podkreśla, że problem przestępczości nieletnich powinien być rozpatrywany przede wszystkim jako problem społeczny, który wymaga reakcji.
Stańdo-Kawecka Barbara
doaj   +1 more source

FY 1998 Juvenile Justice and Delinquency Prevention Act Compliance Monitoring Report [PDF]

open access: yes, 1999
This report was superseded by an amended FY 1998 compliance monitoring report prepared by Eric W. Weatherby, Juvenile Probabation Officer IV, Alaska Division of Juvenile Justice, July 2001.The Juvenile Justice and Delinquency Prevention Act (JJDPA ...
Atwell, Cassie   +2 more
core  

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao   +7 more
wiley   +1 more source

Os menores no Porto : entre o desamparo e o crime (1880-1911)

open access: yesLer História, 2007
From the last quarter of the 19th Century to World War I, important reflections were produced around the situation of the juvenile delinquents and in moral danger, a complex problem that included in its discussion an international multidisciplinal elite.
Maria José Moutinho Santos
doaj   +1 more source

SexTrafficking of Minors: How Many JuvenilesAre Being Prostituted in the US? [PDF]

open access: yes, 2012
There have been many attempts to estimate the number of juveniles who are being prostituted (or trafficked) within the United States. These estimates range from 1,400 to 2.4 mil‐ lion, although most fall between 300,000 and 600,000.
Finkelhor, David, Stransky, Michelle L.
core   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

open access: yesAdvanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen   +8 more
wiley   +1 more source

A breeding site record of Long-billed Vulture Gyps indicus (Aves: Accipitriformes: Accipitridae) from Bejjur Reserve Forest, Telangana, India

open access: yesJournal of Threatened Taxa, 2015
The Long-billed Vulture Gyps indicus is, Critically Endangered with few known breeding sites in peninsular India.  We present a previously undocumented Long-billed Vulture breeding site in Bejjur Reserve Forest, Adilabad District, northern Telangana.
Swetha Stotrabhashyam   +3 more
doaj   +1 more source

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

open access: yesAdvanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang   +21 more
wiley   +1 more source

Home - About - Disclaimer - Privacy