Results 31 to 40 of about 1,870 (108)

Integrative Network Pharmacology and Transcriptomics Reveal the Mechanism of XuanShi Choudong Recipe in the Treatment of Tic Disorder

Brain and Behavior, Volume 16, Issue 8, August 2026.
Using an integrated strategy of network pharmacology and transcriptomics, this study elucidates the therapeutic mechanism of XuanShi Choudong Recipe (CDR) against tic disorder (TD). CDR dose‐dependently alleviates apomorphine‐induced tic‐like stereotypy and hyperlocomotion in rats, restores striatal neurotransmitter homeostasis, and attenuates ...
Hu Jue, Ma Jingying, Chen Yaqin, Pan Yulu, Chen Yanhong, Xu Jiaye, Chen Danfei, Chen Jian, Xuan Xiao‐bo   +8 more
wiley   +1 more source

Effectiveness of Virtual Exercise Intervention in Adults With Major Depressive Disorder: A Systematic Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Virtual reality‐based exercise is an emerging tool in mental health care; however, its application and effectiveness in treating Major Depressive Disorder (MDD) remain unclear. This systematic review evaluated the effectiveness of virtual exercise interventions for adults with MDD, focusing on depressive symptoms, functional ...
Radietya Alvarabie, Elissa Burjawi, Junhua Xiao   +2 more
wiley   +1 more source

Clinician Perspectives of Oxygen Control in Children With Bronchopulmonary Dysplasia at Home: An International Survey of Clinicians From 44 Countries

Journal of Paediatrics and Child Health, Volume 62, Issue 8, Page 1489-1498, August 2026.
ABSTRACT Background Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth and may lead to difficulties with oxygen control even at home. How oxygenation is managed outside the hospital and in high and low resourced settings is unclear. Aims To determine clinician perspectives for managing oxygenation after hospital discharge
Thy A. N. Pham, James X. Sotiropoulos, Abhijeet Rakshasbhuvankar, Vineet Bhandari, Georg M. Schmölzer, R. Kishore Kumar, Satoshi Kusuda, Huayan Zhang, Thu‐Tinh Nguyen, Ratchada Kitsommart, Han‐Suk Kim, Li Ma, Fan Yang, Azanna Ahmad Kamar, Setya Dewi Lusyati, Kee Thai Yeo, Juin Yee Kong, Lloyd Tooke, Dominic Fitzgerald, Kate Gonski, Janneke Dekker, Gina Lim, Victor Javier Lara‐Díaz, Ju Lee Oei   +23 more
wiley   +1 more source

Emerging Immune‐Based Therapeutic Strategies in Hepatocellular Carcinoma

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Hepatocellular carcinoma (HCC) remains a leading cause of cancer‐related mortality worldwide despite recent advances in systemic therapy. The introduction of immune checkpoint inhibitors has substantially expanded treatment options for advanced disease; however, durable responses are observed only in a subset of patients.
Janine Kah, Werner Dammermann, Stefan Lueth   +2 more
wiley   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, Volume 13, Issue 37, 3 July 2026.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Interplay of the ENS and Microbiota With Murine Gut Epithelium‐Derived Organoids in Aging

Aging Cell, Volume 25, Issue 7, July 2026.
A gut organoid model was developed to study the impact of age‐related changes of the enteric nervous system (ENS) and microbiome on the integrity and trophic capacity of the intestinal epithelial barrier. Organoids reflected in vivo aging features, including altered epithelial integrity and changes in acetylcholine‐related enzyme activity.
Tinh Thi Nguyen, Dennis Schapelhouman, Katharina Fischer, Jia‐Xuan Chen, Mario Dejung, Fridolin Kielisch, Julia Varga, Johannes Piepgras, Matthew Ahn, Oliver Tüscher, Peter Baumann, Sandra Schick, Kristina Endres   +12 more
wiley   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, Volume 13, Issue 35, 24 June 2026.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Immunogenic Cell Death: Unlocking New Frontiers in Cancer Immunotherapy

Cancer Innovation, Volume 5, Issue 3, June 2026.
Immunogenic cell death ICD is a specific type of stress‐induced cell death that results in adaptive immune response and generating an immunological memory. The development of strategies that induce ICD are considered highly effective in the treatment of cancer within the bounds of immunotherapy.
Katherine Yaacoub
wiley   +1 more source

Ligand‐Independent Activation of Notch1 by Cathepsin L Induces CUX1/p16INK4a‐Dependent Endothelial Senescence Associated With Atherosclerosis

Aging Cell, Volume 25, Issue 6, June 2026.
CTSL activates Notch1/RBPJ in a ligand‐independent fashion, inducing CUX1/p16INK4a‐dependent endothelial senescence associated with atherosclerosis. ABSTRACT Our post‐GWAS functional analysis revealed that cathepsin L (CTSL) is an upstream regulator of CUX1, and it induces p16INK4a‐dependent and atherosclerosis‐associated senescence by indirectly ...
Yuwei Wu, Lili Lu, Shaoyang Yan, Zewen Du, Danli Jiang, Ting Wu, Qichao Wu, Jie Liu, Johny Ebin, Wei Sun, Partha Dutta, Jay Xiaojun Tan, Jonathan K. Alder, Gang Li   +13 more
wiley   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, Volume 59, Issue 6, June 2026.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source