Results 41 to 50 of about 1,870 (108)

Anti‐Apoptotic and Neurite‐Protective Nanomedicine Augments Embryonic Stem Cells‐Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen, Xiaoyan Jiang, Yuanhui Wang, Zhaobin Luo, Yu Zhang, Siwei Liu, Rui Huang, Dandan Zhang, Zhimin Tang, Yahan Ju, Shaohui Pan, Ni Ni, Wei Feng, Yu Chen, Ping Gu   +14 more
wiley   +1 more source

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu, Meijia Zhang, Maoping Cai, Miao Wang, Ziao Huang, Zesheng Lin, Yixin Liu, Wang Qian, Guopeng Chen, Yuxing Liang, Dongyi Wei, Jing xie, Picheng Yan, Yuanyuan Qu, Yongchang Wei   +14 more
wiley   +1 more source

Additional file 1 of Phase 2 trial of intravenous oncolytic virus JX-594 combined with low-dose cyclophosphamide in patients with advanced breast cancer

Supplementary Material 1: Supplementary Methods and ...
Cousin, Sophie, Toulmonde, Maud, Kind, Michèle, Guegan, Jean-Philippe, Bessede, Alban, Cantarel, Coralie, Bellera, Carine, Italiano, Antoine   +7 more
openaire   +1 more source

635. Systemic Oncolytic and Immunologic Therapy for Cancer with JX-594, a Targeted Poxvirus Expressing GM-CSF

Molecular Therapy, 2006
Kirn, David H., Thorne, Stephen, Kim, J.K., Oh, J.Y., Park, B.H., Lee, D.E., Kim, J.S., Je, J.E., Hwang, Tae-Ho   +8 more
openaire   +1 more source

Additional file 1 of Reshaping the tumor microenvironment of cold soft-tissue sarcomas with oncolytic viral therapy: a phase 2 trial of intratumoral JX-594 combined with avelumab and low-dose cyclophosphamide

Supplementary Material ...
Toulmonde, Maud, Guegan, Jean-Philippe, Spalato-Ceruso, Mariella, Peyraud, Florent, Kind, Michèle, Vanhersecke, Lucile, Le Loarer, François, Perret, Raul, Cantarel, Coralie, Bellera, Carine, Bessede, Alban, Italiano, Antoine   +11 more
openaire   +1 more source

22. The Oncolytic and Immunotherapeutic Vaccinia Virus Pexa-Vec (JX-594) Induces Antibody-Mediated Complement-Dependent Cancer Cell Cytolysis [PDF]

Molecular Therapy, 2013
openaire   +1 more source

Recombinant Oncolytic Viruses: Hexagonal Warriors in the Field of Solid Tumor Immunotherapy. [PDF]

Curr Issues Mol Biol
Zhang C, Sun Q.
europepmc   +1 more source

Advancements on the synergistic application of oncolytic viruses and molecularly targeted therapies for the treatment of solid tumors (Review). [PDF]

Int J Oncol
Bi S, Shan T, Tang Y, Wang Q.
europepmc   +1 more source

376. Clinical Proof-of-Concept with JX-594, a Novel Targeted Multi-Mechanistic Oncolytic Poxvirus, in Patients with Refractory Liver Tumors

Molecular Therapy, 2008
openaire   +1 more source

Enhancing antitumor immunity through oncolytic viruses: advances in genetic engineering. [PDF]

Discov Oncol
Zubair A, Lazarou L, Alkahtani AM, Shahani MY, Afghan N.   +4 more
europepmc   +1 more source