Advanced Science, EarlyView.Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen +13 more
wiley +1 more source
Evidence for alpha–proton abstraction and carbanion formation involving a functional histidine residue in Lentil seedling amine oxidase [PDF]
, 1993 Lentil seedling amine oxidase catalyzes the oxidation of putrescine and in the presence of tetranitromethane gives rise to the formation of nitroform anion.
MEDDA, ROSARIA +3 more
core +1 more source
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
BatteriesReducing greenhouse emissions can be done via the electrification of the transport industry. However, there are challenges related to the electrification such as the lifetime of vehicle batteries as well as limitations on the charging possibilities.
David Geerts +3 more
doaj +1 more source
Low energy and dynamical properties of a single hole in the t-Jz model
Physical review. B, Condensed matter, 1995 RevTex 3.0, 40 pages + 16 Figures in one file self-extracting, to appear in Phys.
ZHONG QF, SORELLA S
openaire +4 more sources
SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening
Advanced Science, EarlyView.Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen +20 more
wiley +1 more source
Assessing Equine Behavioural Responses in Equine-Assisted Services: A Field Study Analysis
AnimalsEquine-Assisted Services (EAS) offer significant benefits for individuals with intellectual and/or physical disabilities. However, ensuring the welfare of the horses involved remains a key ethical concern.
E. Kathalijne Visser +7 more
doaj +1 more source
Generation of Probabilistic Bits by Exploiting Orthogonal Spin Currents in Magnetic Trilayers
Advanced Science, EarlyView.Fe/Ti/CoFeB trilayers generate orthogonal spin currents that drive stochastic spin–orbit‐torque switching for probabilistic‐bit operation. The switching probability is continuously controlled by the in‐plane magnetic field and drive current, enabling tunable random bit generation.
Donghyeon Han +17 more
wiley +1 more source
Brieven van K. Jz. Beukma; bevorens landbouwer op de boerderij Castor, in het kerspel Zuurdijk, gemeente Leens, doch verhuisd naar de Vereenigde Staaten van Noord-Amerika, in den jare 1835, aan deszelfs achtergelaten familie in de provincie Groningen. [PDF]
Letters written from Washington Township, Tippecanoe County, Indiana.Cover-title: Brieven van den landbouwer K. Jz. Beukma ... Op. Nieuw uitgegeven ... Amsterdam, J.C.
Beukma, K. Jz.
core
Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal
Advanced Science, EarlyView.We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao +7 more
wiley +1 more source