Results 171 to 180 of about 9,314,218 (303)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Drama Education with Digital Technology

Drama Education with Digital Technology explores the rapidly evolving intersections between drama, digital gaming, technology and teaching. It documents the praxis (practice and research) that move beyond anecdotal discussion of approaches and design.
Carroll, John., Anderson, Michael., McGeoch, Kirsty., Cameron, David., Flintoff, Kim., Hughes, John., Jefferson, Miranda., Brindley, Sue.   +7 more
core  

Tra equivalenza ed efficacia: la comicità coreana nella traduzione audiovisiva

Traduction et Langues
Between Equivalence and Effectiveness: Korean Humor in Multimedia Translation Humor can be defined as a cognitive experience aimed at eliciting laughter and amusement, particularly when conveyed through language in various forms (cf.
Imsuk Jung, Kukjin Kim
doaj  

Stepping onto the stage: reflections of community-based participatory researchers using Forum Theatre to address the challenges of living with diabetes while experiencing homelessness. [PDF]

Front Public Health
Tariq S, Grewal EK, Larsen M, Auger J, Booth R, Bowdridge B, Lawson J, Whaley A, Johnson NG, Reed T, Bassyouni H, Campbell DJT.   +11 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Cost-effectiveness evaluation of a radio campaign to improve full vaccination coverage among children under-five in Ethiopia. [PDF]

BMC Public Health
Appiah B, Otieku E, Gebretsadik LA, Asefa Y, Kampamba M, Mamo A, Annor C, Morankar S, Mwangilwa K, Fenny AP.   +9 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

When Portal Venous Gas Is Not Catastrophic: Accidental Hydrogen Peroxide Ingestion Managed Conservatively. [PDF]

Maedica (Bucur)
Andronikou A, Papadopoulos C, Kouskos E, Pegios A, Dinaki K.   +4 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source