Results 171 to 180 of about 1,880,140 (284)

Mapping transcriptional patterns of MPXV in human epithelial cells. [PDF]

Emerg Microbes Infect
Picarone L, Pietrucci D, Mariotti D, Milanesi M, Mija C, Bordi L, Meschi S, Mazzotta V, Gruber CEM, Mavian C, Girardi E, Antinori A, Matusali G, Chillemi G, Maggi F.   +14 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Single-position ligand modifications tune CB₂R activity by targeting the toggle switch. [PDF]

Chem Sci
Ganzoni RLZ, Kosar M, Han Y, Vitale RM, Amodeo P, Li X, Zha Z, Patej KJ, Kicin B, Strunden TEN, Reichert L, Gómez-Bouzó U, Perera TP, Atz K, Guba W, Bartelmus C, Bigler R, Tosatti P, Bachmann S, Hua T, Sykes DA, Veprintsev DB, Grether U, Carreira EM.   +23 more
europepmc   +1 more source

The K-functional for rearrangement invariant spaces [PDF]

Studia Mathematica, 1979
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A systematic comparison of density functional methods for determining spin-state energy gaps and spin transition temperature of spin crossover complexes. [PDF]

RSC Adv
Gera E, Vignesh KR.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Subtype-specific enhancement of implicit statistical learning in migraine: insights from BOLD signal variability. [PDF]

J Headache Pain
Kocsis K, Szücs-Bencze L, Csomós M, Veréb D, Horváth L, Dominika K, Szuly KA, Faragó P, Tuka B, Kincses ZT, Szabó N.   +10 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source