Results 181 to 190 of about 1,851,528 (313)

A Possible Recently Identified Evolutionary Strategy Using Membrane-Bound Vesicle Transfer of Genetic Material to Induce Bacterial Resistance, Virulence and Pathogenicity in Klebsiella oxytoca. [PDF]

Int J Mol Sci
Tamayo-Ordóñez YJ, Rosas-García NM, Bello-López JM, Tamayo-Ordóñez MC, Tamayo-Ordóñez FA, Calzada-Mendoza CC, Ayil-Gutiérrez BA.   +6 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

SORLA/SORL1 Functionally Interacts with SPAK To Control Renal Activation of Na⁺-K⁺-Cl⁻ Cotransporter 2

, 2010
Juliane Reiche, Franziska Theilig, Fatema H. Rafiqi, Anne-Sophie Carlo, Daniel Militz, Kerim Mutig, Mihail Todiraş, Erik Christensen, David H. Ellison, Michael Bäder, Anders Nykjær, Sebastian Bachmann, Dario R. Alessi, Thomas E. Willnow   +13 more
openalex   +1 more source

One-shot K-region-selective annulative π-extension for nanographene synthesis and functionalization [PDF]

, 2015
Kyohei Ozaki, Katsuaki Kawasumi, Mari Shibata, Hideto Ito, Kenichiro Itami   +4 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Realizing the Future State of K-12 Public Education: Data Exchange and Functional Integration with Local Government

, 2014
Patrick J. Simon, Jürgen Heumann
openalex   +2 more sources

A Structural View on the Functional Importance of the Sugar Moiety and Steroid Hydroxyls of Cardiotonic Steroids in Binding to Na,K-ATPase* [PDF]

, 2013
Flemming Cornelius, R. Kanai, Chikashi Toyoshima   +2 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Functional Trait Space Reveals Resource Use Strategies of Woody Plants in the Lijiang River Basin. [PDF]

Ecol Evol
Duan BJ, Wei SG, Li L, Bai KD, Li XJ, Yin YH, Wang X, Hu Y.   +7 more
europepmc   +1 more source

Bimetallic [Co/K] hydrogen evolution catalyst for electrochemical terminal C-H functionalization [PDF]

Sheng Zhang, Lei Hong, Jiayi Feng, Mohan Wang, Junyuan Hu, Ying Zhang, Man‐Bo Li   +6 more
openalex   +1 more source